Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.49 |
| ▸ | ALB | P02768 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL121108 | 0.90 | PTGS2 (0.61) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| SCHEMBL598280 | 0.90 | PTGS2 (0.61) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| SCHEMBL1590331 | 0.90 | PTGS2 (0.61) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| Hydrochloric Acid SCHEMBL5846545 | 0.88 | PTGS2 (0.59) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| SCHEMBL11884258 | 0.85 | PTGS2 (0.71) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| Guanidine SCHEMBL5344605 | 0.82 | PTGS2 (0.62) | PTGS2PTGS1CYP2C9LMNAAKR1C3 | |
| SCHEMBL7794207 | 0.80 | EPHX1 (0.58) | CYP2C9LMNANFKB1TSHRBLM | |
| SCHEMBL607802 | 0.80 | EPHX1 (0.58) | CYP2C9LMNANFKB1TSHRBLM | |
| SCHEMBL607803 | 0.80 | EPHX1 (0.58) | CYP2C9LMNANFKB1TSHRBLM | |
| SCHEMBL11568894 | 0.80 | PTGS2 (0.50) | PTGS2PTGS1CYP2C9LMNAAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7204588-B2 | Ink jet printed matter | KONICA CORPORATION (JP) | 2007-04-17 | — | — | US | disclosed |
| US-20030202082-A1 | Ink jet printed matter | KONICA CORPORATION (JP) | 2003-10-30 | — | — | US | disclosed |