Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.57 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.57 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | RARB | P10826 | 1/20 | 0.57 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.57 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.57 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL598280 | 1.00 | PTGS2 (0.61) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL121108 | 1.00 | PTGS2 (0.61) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| Hydrochloric Acid SCHEMBL5846545 | 0.98 | PTGS2 (0.59) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL11884258 | 0.94 | PTGS2 (0.71) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| Guanidine SCHEMBL5348313 | 0.90 | PTGS2 (0.52) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL11568894 | 0.89 | PTGS2 (0.50) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL59197 | 0.88 | PTGS2 (0.74) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL15695554 | 0.86 | BRD4 (0.61) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL12225982 | 0.86 | BRD4 (0.61) | PTGS2PTGS1LMNACYP2C9AKR1C3 | |
| SCHEMBL6551674 | 0.86 | PTGS2 (0.65) | PTGS2PTGS1LMNACYP2C9AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2752419-B1 | SPIROBENZYLAMINE-PHOSPHINE, PREPARATION METHOD THEREFOR AND USE THEREOF | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2019-01-02 | — | — | EP | disclosed |
| EP-2251316-B1 | METHOD FOR PRODUCING OPTICALLY ACTIVE ESTER AND METHOD FOR PRODUCING OPTICALLY ACTIVE CARBOXYLIC ACID | TOKYO UNIV OF SCIENCE EDUCATIONAL FOUNDATION ADMINISTRATIVE ORGANIZATION (JP) | 2018-02-21 | — | — | EP | disclosed |
| EP-1933622-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-03-09 | — | — | EP | disclosed |
| US-9108995-B2 | Spirobenzylamine-phosphine, preparation method therefor and use thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2015-08-18 | — | — | US | disclosed |
| US-9108995-B2 | Spirobenzylamine-phosphine, preparation method therefor and use thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2015-08-18 | — | — | US | disclosed |
| US-20140194638-A1 | Spirobenzylamine-Phosphine, Preparation Method Therefor And Use Thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-07-10 | — | — | US | disclosed |
| US-20140194638-A1 | Spirobenzylamine-Phosphine, Preparation Method Therefor And Use Thereof | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-07-10 | — | — | US | disclosed |
| EP-2752419-A1 | SPIROBENZYLAMINE-PHOSPHINE, PREPARATION METHOD THEREFOR AND USE THEREOF | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2014-07-09 | — | — | EP | disclosed |
| US-20140135520-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | Tokyo University of Science Educational Foundation Administration Organization (JP) | 2014-05-15 | — | — | US | disclosed |
| EP-2719679-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | Tokyo University Of Science Educational Foundation Administrative Organization (JP) | 2014-04-16 | — | — | EP | disclosed |
| WO-2007109192-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |
| US-20070225324-A1 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | SECOND GENOME, INC. | 2007-09-27 | — | — | US | disclosed |
| US-7199135-B2 | Substituted alkyl amido piperidines | H. LUNDBECK A/S (DK) | 2007-04-03 | — | — | US | disclosed |
| US-20060217418-A1 | Substituted alkyl amido piperidines | H. LUNDBECK A/S (DK) | 2006-09-28 | — | — | US | disclosed |
| US-20060084649-A9 | Substituted alkyl amido piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2006-04-20 | — | — | US | disclosed |
| CN-1735595-A | Substituted alkyl amido piperidines | LUNDBECK & CO AS H (DK) | 2006-02-15 | — | — | CN | disclosed |
| EP-1590326-A2 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | H. Lundbeck A/S (DK) | 2005-11-02 | — | — | EP | disclosed |
| US-20040186103-A1 | Substituted alkyl amido piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-09-23 | — | — | US | disclosed |
| WO-2004064764-A2 | SUBSTITUTED ALKYL AMIDO PIPERIDINES | H. LUNDBECK A/S (DK) | 2004-08-05 | — | — | WO | disclosed |
| EP-0759425-A2 | Process for the preparation of optically active 1-aryl-alkylamines | BAYER AG (DE) | 1997-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084649-A9 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | PTGS2 3508/4885PTGS1 1552/4885LMNA 3611/4885 |
| US-20070225324-A1 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | P2RX7, P2RX3, P2RX2 | PTGS2 204/4885PTGS1 130/4885LMNA 1911/4885 |
| US-20060217418-A1 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | PTGS2 3508/4885PTGS1 1552/4885LMNA 3611/4885 |
| US-20140135520-A1 | METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBOXYLIC ACID ESTER | ALDH1A2, ADH1C, ADH1A | PTGS2 2021/4885PTGS1 2304/4885LMNA 3362/4885 |
| US-20040186103-A1 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | PTGS2 3508/4885PTGS1 1552/4885LMNA 3611/4885 |
| US-20140194638-A1 | Spirobenzylamine-Phosphine, Preparation Method Therefor And Use Thereof | FAR1, WEE1, ALDH7A1 | PTGS2 3262/4885PTGS1 1814/4885LMNA 4351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.