Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5350286 | 0.79 | ALDH1A1 (0.43) | ACHEMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL4264863 | 0.74 | MCHR1 (0.56) | MCHR1TLR8TLR7 | |
| SCHEMBL4816102 | 0.72 | POLB (0.43) | ACHEMAPTMCHR1ALDH1A1HSD17B10 | |
| SCHEMBL4818208 | 0.71 | MCHR1 (0.48) | MCHR1TLR8TLR7 | |
| SCHEMBL5358262 | 0.71 | ALDH1A1 (0.42) | MCHR1ALDH1A1HSD17B10NQO2CASP1 | |
| SCHEMBL28476846 | 0.70 | PLAU (0.52) | ACHEMAPTALDH1A1HSD17B10KDM4E | |
| SCHEMBL5349078 | 0.70 | MCHR1 (0.47) | ACHEMAPTMCHR1ALDH1A1HSD17B10 | |
| SCHEMBL5352801 | 0.70 | MCHR1 (0.47) | ACHEMAPTMCHR1ALDH1A1HSD17B10 | |
| SCHEMBL30140206 | 0.70 | DYRK1A (0.38) | ACHEMAPTKDM4ETYMSDYRK1A | |
| SCHEMBL4819395 | 0.70 | CYSLTR1 (0.49) | MAPTALDH1A1HSD17B10KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189714-B2 | N-type calcium channel antagonists for the treatment of pain | ASTRAZENECA AB (SE) | 2007-03-13 | — | — | US | disclosed |