Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5366354 | 0.98 | MAPT (0.48) | MCHR1MAPTKDM4EGFERALDH1A1 | |
| SCHEMBL5352801 | 0.97 | MCHR1 (0.47) | MCHR1MAPTKDM4EGFERALDH1A1 | |
| SCHEMBL4816102 | 0.93 | POLB (0.43) | MCHR1MAPTKDM4EGFERALDH1A1 | |
| SCHEMBL4817686 | 0.79 | DHODH (0.53) | MAPTKDM4EGFERALDH1A1NPC1 | |
| SCHEMBL28476846 | 0.71 | PLAU (0.52) | MAPTKDM4EALDH1A1SMN1; SMN2ACHE | |
| SCHEMBL5348766 | 0.70 | ACHE (0.38) | MCHR1MAPTKDM4EGFERALDH1A1 | |
| SCHEMBL5347416 | 0.69 | PLAU (0.55) | MAPTKDM4EGFERALDH1A1NPC1 | |
| SCHEMBL5356709 | 0.69 | MCHR1 (0.55) | MCHR1MAPTKDM4ENPC1RAB9A | |
| SCHEMBL17786499 | 0.69 | KDM4E (0.64) | MAPTKDM4EGFERALDH1A1NPC1 | |
| SCHEMBL30998387 | 0.69 | HRH4 (0.50) | KDM4EALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189714-B2 | N-type calcium channel antagonists for the treatment of pain | ASTRAZENECA AB (SE) | 2007-03-13 | — | — | US | disclosed |