Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | SLC18A2 | Q05940 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14920157 | 0.87 | SLC6A2 (0.52) | SLC6A3 | |
| SCHEMBL557124 | 0.86 | TACR1 (0.47) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14920858 | 0.85 | — | — | |
| SCHEMBL14919954 | 0.82 | GAA (0.48) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL527575 | 0.81 | SLC6A2 (0.50) | SLC6A3 | |
| SCHEMBL4321575 | 0.80 | PDE4A (0.45) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL15013795 | 0.80 | ALDH1A1 (0.44) | ALDH1A1RECQL | |
| SCHEMBL14920315 | 0.78 | SLC18A2 (0.46) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18272434 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HTR2A | |
| SCHEMBL18272435 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2413941-A1 | RENIN INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010114978-A1 | RENIN INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-10-07 | — | — | WO | disclosed |