Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29892764 | 0.70 | HPGD (0.47) | HPGDHCAR3FGFR1HSD17B10GAA | |
| SCHEMBL5362222 | 0.69 | HCAR3 (0.49) | HPGDHCAR3FGFR1HSD17B10GAA | |
| SCHEMBL5351179 | 0.69 | ADORA1 (0.45) | HPGDHCAR3HSD17B10THRBALDH1A1 | |
| SCHEMBL10745104 | 0.67 | KDM4E (0.40) | HPGDHCAR3HSD17B10GAAALDH1A1 | |
| SCHEMBL824442 | 0.66 | HSD17B10 (0.53) | HPGDHCAR3FGFR1HSD17B10GAA | |
| SCHEMBL29892844 | 0.65 | HSD17B10 (0.55) | HPGDHCAR3FGFR1HSD17B10GAA | |
| SCHEMBL31461005 | 0.65 | HCAR3 (0.47) | HPGDHCAR3FGFR1HSD17B10GAA | |
| SCHEMBL599310 | 0.64 | HCAR3 (0.65) | HPGDHCAR3FGFR1HSD17B10GAA | |
| SCHEMBL20996080 | 0.64 | CHEK1 (0.39) | CHEK1 | |
| SCHEMBL28227235 | 0.64 | FGFR1 (0.60) | HPGDHCAR3FGFR1HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202245-B2 | Substituted 4-amino[1,2,4]triazolo[4,3-a] quinoxalines | PFIZER INC. (US) | 2007-04-10 | — | — | US | disclosed |