SCHEMBL535242

SCHEMBL535242

Nc1ccc([N+](=O)[O-])c(O)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.74
HSD17B10 Q99714 2/20 0.74
MAPK1 P28482 2/20 0.74
L3MBTL1 Q9Y468 1/20 0.74
TDP1 Q9NUW8 4/20 0.67
TSHR P16473 4/20 0.67
GPR35 Q9HC97 2/20 0.64
ALDH1A1 P00352 6/20 0.61
CYP3A4 P08684 5/20 0.61
RECQL P46063 2/20 0.57
HPGD P15428 3/20 0.49
MAPT P10636 3/20 0.49
KDM4E B2RXH2 2/20 0.49
POLB P06746 2/20 0.49
LMNA P02545 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP2C9 P11712 1/20 0.49
BLM P54132 1/20 0.49
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29960275 0.85 ALOX15 (1.00) ALOX15HSD17B10MAPK1L3MBTL1TDP1
SCHEMBL56850 0.85 ALOX15 (1.00) ALOX15HSD17B10MAPK1L3MBTL1TDP1
SCHEMBL28683992 0.83 ALOX15 (0.96) ALOX15HSD17B10MAPK1L3MBTL1TDP1
SCHEMBL30002802 0.83 ALOX15 (0.96) ALOX15HSD17B10MAPK1L3MBTL1TDP1
Hydrochloric Acid SCHEMBL30948365 0.83 ALOX15 (0.96) ALOX15HSD17B10MAPK1L3MBTL1TDP1
SCHEMBL1254184 0.82 TDP1 (0.72) ALOX15HSD17B10MAPK1L3MBTL1TDP1
SCHEMBL29378383 0.80 TDP1 (1.00) ALOX15HSD17B10MAPK1L3MBTL1TDP1
SCHEMBL121896 0.80 TDP1 (1.00) ALOX15HSD17B10MAPK1L3MBTL1TDP1
SCHEMBL68980 0.80 GPR35 (0.67) ALOX15HSD17B10MAPK1L3MBTL1TDP1
SCHEMBL9198198 0.80 GPR35 (0.67) ALOX15HSD17B10MAPK1L3MBTL1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659399-B1 Process of direct hair using steam OREAL (FR) 1997-03-19 EP claimed
US-5496377-A HAIR DYES, NITRO-AMINE COMPOUNDS L'OREAL (FR) 1996-03-05 US claimed
EP-0659399-A1 Process of direct hair using steam L'OREAL (FR) 1995-06-28 EP claimed
US-4311478-A HAIR DYES L'OREAL (FR) 1982-01-19 US claimed
US-4152112-A Dyeing composition for keratinic fibers containing paraphenylenediamines L'OREAL (FR) 1979-05-01 US claimed
JP-9255636-A None JP disclosed
EP-4653870-A1 METHOD AND REAGENT FOR QUANTIFYING PROTEIN Nitto Boseki Co., Ltd. (JP) 2025-11-26 EP disclosed
CN-120153260-A Method and reagent for quantifying protein 日东纺绩株式会社 2025-06-13 CN disclosed
WO-2024154593-A1 METHOD AND REAGENT FOR QUANTIFYING PROTEIN 日東紡績株式会社 2024-07-25 WO disclosed
EP-3222620-A1 CYANOQUINOLINE DERIVATIVES TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2017-09-27 EP disclosed
US-20170226093-A1 CYANOQUINOLINE DERIVATIVES TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2017-08-10 US disclosed
US-9676724-B2 Cyanoquinoline derivatives TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2017-06-13 US disclosed
US-4566875-A HAIR DYES L'OREAL (FR) 1986-01-28 US disclosed
US-4417896-A NITRO-,AMINO-,PHENOXYALKANOLS SOCIETE ANONYME DITE: L'OREAL (FR) 1983-11-29 US disclosed
US-4337061-A NITRO DYES IN AQUEOUS SOLUTION SOCIETE ANONYME DITE: L'OREAL (FR) 1982-06-29 US disclosed
US-4311478-A HAIR DYES L'OREAL (FR) 1982-01-19 US disclosed
US-4295848-A Composition for hair dyeing which contains a para base and an ortho base L'OREAL (FR) 1981-10-20 US disclosed
US-4268264-A ORTHO PRECURSORS SELECTED FROM AROMATIC DIAMINES, AMINOPHENOL, DIPHENOL, AND PHENYLENEDIAMINE L'OREAL (FR) 1981-05-19 US disclosed
US-4152112-A Dyeing composition for keratinic fibers containing paraphenylenediamines L'OREAL (FR) 1979-05-01 US disclosed
US-4094635-A Meta-aminophenol sulfonamides as couplers in hair dye compositions L'OREAL (FR) 1978-06-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170226093-A1 CYANOQUINOLINE DERIVATIVES CBR3, CYP3A4, CDK1 ALOX15 4518/4885HSD17B10 1457/4885MAPK1 2443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.