Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11757083 | 0.87 | NOS3 (0.35) | NOS3NOS2 | |
| SCHEMBL503238 | 0.84 | NOS3 (0.36) | NOS3NOS2ESR1 | |
| SCHEMBL14018704 | 0.78 | NOS3 (0.43) | NOS3NOS2ESR1KDM5BHRH3 | |
| SCHEMBL10051193 | 0.74 | NOS3 (0.50) | NOS3NOS2ESR1KDM5BHRH3 | |
| SCHEMBL12228994 | 0.74 | NOS3 (0.44) | NOS3NOS2ESR1KDM5BHRH3 | |
| SCHEMBL1576980 | 0.72 | NOS3 (0.54) | NOS3NOS2HRH3 | |
| SCHEMBL12309955 | 0.72 | NOS3 (0.43) | NOS3NOS2ESR1KDM5BHRH3 | |
| SCHEMBL14146445 | 0.70 | NOS3 (0.42) | NOS3NOS2ESR1KDM5BHRH3 | |
| SCHEMBL9130357 | 0.70 | NOS2 (0.57) | NOS3NOS2ESR1 | |
| SCHEMBL9126124 | 0.70 | NOS3 (0.38) | NOS3NOS2ESR1KDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101514190-B | Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis | UNIV DONGHUA | 2011-06-08 | — | — | CN | claimed |
| CN-101391984-B | Method for carrying out methylation to pyrimidine heterocyclic compound containing sulfhydryl by dimethyl carbonate | UNIV DONGHUA | 2010-12-08 | — | — | CN | claimed |
| CN-101514190-A | Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis | UNIV DONGHUA (CN) | 2009-08-26 | — | — | CN | claimed |
| CN-101391984-A | Method for carrying out methylation to pyrimidine heterocyclic compound containing sulfhydryl by dimethyl carbonate | UNIV DONGHUA (CN) | 2009-03-25 | — | — | CN | claimed |
| EP-0497371-A1 | Pyrimidinyloxy(thio)quinoline derivatives, preparation process of the derivative, and agri-horticultural fungicide comprising the derivative as active ingredient | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-08-05 | — | — | EP | claimed |
| CN-101514190-B | Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis | UNIV DONGHUA | 2011-06-08 | — | — | CN | disclosed |
| CN-101391984-B | Method for carrying out methylation to pyrimidine heterocyclic compound containing sulfhydryl by dimethyl carbonate | UNIV DONGHUA | 2010-12-08 | — | — | CN | disclosed |
| CN-101514190-A | Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis | UNIV DONGHUA (CN) | 2009-08-26 | — | — | CN | disclosed |
| CN-101391984-A | Method for carrying out methylation to pyrimidine heterocyclic compound containing sulfhydryl by dimethyl carbonate | UNIV DONGHUA (CN) | 2009-03-25 | — | — | CN | disclosed |
| US-7238685-B2 | Benzo-fused heterocycles as endothelin antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-07-03 | — | — | US | disclosed |
| US-20050124605-A1 | Novel benzo-fused heterocycles as endothelin antagonisits | ACTELION PHARMACEUTICALS LTD. | 2005-06-09 | — | — | US | disclosed |
| WO-2003013545-A1 | NOVEL BENZO-FUSED HETEROCYCLES AS ENDOTHELIN ANTAGONISITS | ACTELION PHARMACEUTICALS LTD (CH) | 2003-02-20 | — | — | WO | disclosed |
| EP-0497371-B1 | Pyrimidinyloxy(thio)quinoline derivatives, preparation process of the derivative, and agri-horticultural fungicide comprising the derivative as active ingredient | MITSUI CHEMICALS INC (JP) | 1998-06-24 | — | — | EP | disclosed |
| US-5202329-A | Pyrimidinyloxy(thio)quinoline derivative, and agri-horticultural fungicide comprising the derivative as active ingredient | MITSUI TOATSU CHEMICALS INC. (JP) | 1993-04-13 | — | — | US | disclosed |
| EP-0497371-A1 | Pyrimidinyloxy(thio)quinoline derivatives, preparation process of the derivative, and agri-horticultural fungicide comprising the derivative as active ingredient | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1992-08-05 | — | — | EP | disclosed |
| EP-0137223-B1 | PHOTOGRAPHIC IMAGE-RECEIVING ELEMENT FOR SILVER SALT DIFFUSION TRANSFER PROCESS | FUJI PHOTO FILM CO., LTD. (JP) | 1988-05-11 | — | — | EP | disclosed |
| US-4585725-A | STORAGE STABILITY | FUJI PHOTO FILM CO., LTD. (JP) | 1986-04-29 | — | — | US | disclosed |
| EP-0137223-A2 | Photographic image-receiving element for silver salt diffusion transfer process | FUJI PHOTO FILM CO., LTD. (JP) | 1985-04-17 | — | — | EP | disclosed |
| US-3963495-A | Image-receiving element for silver salt diffusion transfer with layer of monoacrylates or monomethacrylates of polyhydric alcohols | FUJI PHOTO FILM CO., LTD. (JA) | 1976-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124605-A1 | Novel benzo-fused heterocycles as endothelin antagonisits | EDNRA, EDNRB, ECE1 | NOS3 493/4885NOS2 440/4885ESR1 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.