Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.65 |
| ▸ | HPGDS | O60760 | 1/20 | 0.63 |
| ▸ | CDC25B | P30305 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | STAT6 | P42226 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | EP300 | Q09472 | 1/20 | 0.52 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10964177 | 0.89 | CDC25B (0.53) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL30742731 | 0.89 | CDC25B (0.53) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL4469856 | 0.83 | CDC25B (0.78) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL7842295 | 0.83 | PLK1 (0.67) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL4518755 | 0.83 | PLK1 (0.67) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL698753 | 0.83 | NQO1 (0.65) | PLK1HPGDSCDC25BKMT2AHPGD | |
| SCHEMBL28639283 | 0.82 | ATM (0.75) | KMT2AMAPTHPGDALDH1A1CYP3A4 | |
| SCHEMBL24101354 | 0.81 | PLK1 (0.70) | PLK1HPGDSCDC25BKMT2AMAPT | |
| SCHEMBL4028585 | 0.81 | PLK1 (0.65) | PLK1HPGDSCDC25BKMT2AMAPT | |
| Hydrochloric Acid SCHEMBL11445757 | 0.81 | CDC25B (0.76) | PLK1HPGDSCDC25BKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007503382-A | — | — | 2007-02-22 | — | — | JP | claimed |
| US-20060281897-A1 | Potentialization of the activation of high molecular weight prodrugs | DIATOS S.A. (FR) | 2006-12-14 | — | — | US | claimed |
| EP-1701743-A2 | POTENTIATION OF THE ACTIVATION OF HIGH-MOLECULAR-MASS PRODRUGS | Diatos (FR) | 2006-09-20 | — | — | EP | claimed |
| WO-2005021043-A2 | HIGH-MOLECULAR-MASS PRODRUGS | DIATOS (FR) | 2005-03-10 | — | — | WO | claimed |
| EP-2945930-B1 | NOVEL DDP-IV INHIBITORS | DNJ PHARMA INC (US) | 2018-10-10 | — | — | EP | disclosed |
| US-20160011195-A1 | Method of Forming Fragment Ligated Inhibitors | UNIVERSITY OF SOUTH CAROLINA | 2016-01-14 | — | — | US | disclosed |
| US-20150315555-A1 | Fragment Ligated Inhibitors Selective for the Polo Box Domain of PLK1 | UNIVERSITY OF SOUTH CAROLINA | 2015-11-05 | — | — | US | disclosed |
| US-9175357-B2 | Fragment ligated inhibitors selective for the polo box domain of PLK1 | UNIVERSITY OF SOUTH CAROLINA (US) | 2015-11-03 | — | — | US | disclosed |
| EP-2276776-B1 | METHOD AND AFFINITY COLUMN FOR PURIFYING PROTEINS | SAMSUNG ELECTRONICS CO LTD (KR) | 2015-07-29 | — | — | EP | disclosed |
| US-20120115207-A1 | ENHANCED PRODUCTION OF PAPILLOMAVIRUS-LIKE PARTICLES WITH A MODIFIED BACULOVIRUS EXPRESSION SYSTEM | DEUTSCHES KREBSFORSCHUNGSZENTRUM | 2012-05-10 | — | — | US | disclosed |
| EP-2414512-A1 | ENHANCED PRODUCTION OF PAPILLOMAVIRUS-LIKE PARTICLES WITH A MODIFIED BACULOVIRUS EXPRESSION SYSTEM | Deutsches Krebsforschungszentrum (DE) | 2012-02-08 | — | — | EP | disclosed |
| US-20110236367-A1 | RAT CATHESPIN DIPEPTIDYL PEPTIDASE I (DPPI): CRYSTAL STRUCTURE AND ITS USES | TELENAV, INC. (US) | 2011-09-29 | — | — | US | disclosed |
| EP-1176191-B1 | ALPHA-GLYCATED AMINO ACID RELEASING ENZYME | ARKRAY INC (JP) | 2004-09-01 | — | — | EP | disclosed |
| US-20040043469-A1 | Dipeptidyl peptidase i crystal structure and its uses | PROZYMEX A/S (DK) | 2004-03-04 | — | — | US | disclosed |
| EP-0791071-B1 | ASSAY FOR PROLINE IMINOPEPTIDASE AND OTHER HYDROLYTIC ACTIVITIES | LITMUS CONCEPTS INC (US) | 1999-09-15 | — | — | EP | disclosed |
| WO-1997049653-A9 | SOLID PHASE TYRPHOSTIN LIBRARY LINKED TO MATRICES WITH MEMORIES | — | 1998-04-16 | — | — | WO | disclosed |
| EP-0800528-A1 | PEPTIDE AND PEPTIDE ANALOG PROTEASE INHIBITORS | Sibia Neurosciences, Inc. (US) | 1997-10-15 | — | — | EP | disclosed |
| EP-0791071-A1 | ASSAY FOR PROLINE IMINOPEPTIDASE AND OTHER HYDROLYTIC ACTIVITIES | LITMUS CONCEPTS, INC. (US) | 1997-08-27 | — | — | EP | disclosed |
| US-5571684-A | SOLID PHASE CONJUGATE | LITMUS CONCEPTS, INC. (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1996015255-A2 | ASSAY FOR PROLINE IMINOPEPTIDASE AND OTHER HYDROLYTIC ACTIVITIES | LITMUS CONCEPTS, INC. (US) | 1996-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150315555-A1 | Fragment Ligated Inhibitors Selective for the Polo Box Domain of PLK1 | PLK1, POLD1, CTDSP1 | PLK1 1/4885HPGDS 1808/4885CDC25B 113/4885 |
| US-20160011195-A1 | Method of Forming Fragment Ligated Inhibitors | PLK1, POLD1, POLR1E | PLK1 1/4885HPGDS 1867/4885CDC25B 80/4885 |
| US-20060281897-A1 | Potentialization of the activation of high molecular weight prodrugs | CD44, MMP12, FOLH1 | PLK1 479/4885HPGDS 209/4885CDC25B 544/4885 |
| US-20110236367-A1 | RAT CATHESPIN DIPEPTIDYL PEPTIDASE I (DPPI): CRYSTAL STRUCTURE AND ITS USES | DPP3, DPP7, DPP4 | PLK1 3977/4885HPGDS 3893/4885CDC25B 3283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.