Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 13/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9311868 | 0.99 | MAPK10 (0.59) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| SCHEMBL6715175 | 0.88 | PKM (0.57) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| SCHEMBL31011321 | 0.85 | ALDH1A1 (0.76) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| SCHEMBL28180887 | 0.85 | ALDH1A1 (0.76) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| SCHEMBL9311736 | 0.83 | MAPK10 (0.61) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| SCHEMBL7066626 | 0.82 | MAPK10 (0.49) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| Hydrochloric Acid SCHEMBL9312979 | 0.82 | MAPK10 (0.60) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| SCHEMBL9312347 | 0.82 | MAPK10 (0.63) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| SCHEMBL12567716 | 0.81 | ALDH1A1 (0.65) | MAPK10LMNAALDH1A1MAPK14MAPK9 | |
| SCHEMBL29498350 | 0.81 | ALDH1A1 (0.65) | MAPK10LMNAALDH1A1MAPK14MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3145469-A | — | — | None | — | — | JP | disclosed |
| CN-100418955-C | Novel Benzo-fused heterocycles | ACTELION PHARMOUEUTICALS LTD (CH) | 2008-09-17 | — | — | CN | disclosed |
| US-7238685-B2 | Benzo-fused heterocycles as endothelin antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2007-07-03 | — | — | US | disclosed |
| US-20050124605-A1 | Novel benzo-fused heterocycles as endothelin antagonisits | ACTELION PHARMACEUTICALS LTD. | 2005-06-09 | — | — | US | disclosed |
| WO-2003013545-A1 | NOVEL BENZO-FUSED HETEROCYCLES AS ENDOTHELIN ANTAGONISITS | ACTELION PHARMACEUTICALS LTD (CH) | 2003-02-20 | — | — | WO | disclosed |
| US-RE34630-E | Antagonist for platelet activating factor | EUROCELTIQUE, S.A. (LU) | 1994-06-07 | — | — | US | disclosed |
| JP-H03145469-A | SUBSTITUTED ISOQUINOLINE AND USE OF THE SAME | EURO CELTIQUE SA | 1991-06-20 | — | — | JP | disclosed |
| EP-0422328-A2 | Substituted isoquinolines and their use | Euro-Celtique S.A. (LU) | 1991-04-17 | — | — | EP | disclosed |
| US-4956371-A | PLATELET ACTIVATING FACTOR | EUROCELTIQUE, S.A. (LU) | 1990-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124605-A1 | Novel benzo-fused heterocycles as endothelin antagonisits | EDNRA, EDNRB, ECE1 | MAPK10 2091/4885LMNA 983/4885ALDH1A1 3710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.