Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1555927 | 0.87 | SLC6A9 (0.50) | OPRL1CYP2D6HSD11B1SLC6A9MEN1 | |
| SCHEMBL5345057 | 0.80 | HSD11B1 (0.47) | OPRL1CYP3A4ALDH1A1HPGDHSD11B1 | |
| SCHEMBL18681238 | 0.74 | SLC6A9 (0.40) | OPRL1HSD11B1SLC6A9 | |
| SCHEMBL2298882 | 0.73 | HSD11B1 (0.76) | HSD11B1 | |
| SCHEMBL2300119 | 0.73 | HSD11B1 (0.60) | HSD11B1MEN1KMT2A | |
| SCHEMBL19851208 | 0.71 | OPRL1 (0.45) | OPRL1CYP2D6CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL19852918 | 0.71 | HSD11B1 (0.48) | OPRL1HSD11B1SLC6A9 | |
| SCHEMBL19851211 | 0.70 | OPRL1 (0.44) | OPRL1CYP2C19ALDH1A1HPGDSLC6A9 | |
| SCHEMBL19851209 | 0.70 | OPRL1 (0.50) | OPRL1CYP2D6CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL21225675 | 0.69 | SLC6A9 (0.44) | OPRL1ALDH1A1HSD11B1SLC6A9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007084314-A2 | MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-07-26 | — | — | WO | claimed |