Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NNMT | P40261 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL926767 | 0.86 | ERN1 (0.46) | ERN1TDP1SIRT3GRM1KDM4E | |
| SCHEMBL5515911 | 0.84 | ERN1 (0.44) | ERN1TDP1SIRT3GRM1KDM4E | |
| SCHEMBL14880244 | 0.83 | MEN1 (0.49) | ERN1GRM1KDM4EALDH1A1MAPT | |
| SCHEMBL4132985 | 0.82 | KMT2A (0.46) | TDP1GRM1KDM4EALDH1A1MAPT | |
| SCHEMBL354227 | 0.82 | SIRT3 (0.45) | TDP1SIRT3KDM4EALDH1A1MAPT | |
| SCHEMBL6667388 | 0.80 | MAPT (0.47) | TDP1GRM1KDM4EALDH1A1MAPT | |
| SCHEMBL30149140 | 0.80 | ALDH1A1 (0.57) | TDP1GRM1KDM4EALDH1A1MAPT | |
| SCHEMBL317576 | 0.80 | ALDH1A1 (0.57) | TDP1GRM1KDM4EALDH1A1MAPT | |
| SCHEMBL32678438 | 0.80 | MAPT (0.47) | TDP1GRM1KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL1776795 | 0.80 | SIRT3 (0.44) | TDP1SIRT3KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103626766-B | With the synthesis of the heterocyclic fused γ carbolines of substitution | 细胞内治疗公司 | 2017-06-09 | — | — | CN | claimed |
| WO-2007134421-A1 | 2-VINYL INDOLES, PYRIDO AND AZEPINO INDOLE DERIVATIVES, 2-ALKYNYL INDOLES, 2-ALKYNYL BENZO[b]FURANS, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF | LAUTENS MARK (CA) | 2007-11-29 | — | — | WO | claimed |
| CN-113227045-A | Synthesis of substituted heterocycle fused gamma-carbolines | 细胞内治疗公司 | 2021-08-06 | — | — | CN | disclosed |
| CN-113195450-A | Synthesis of substituted heterocycle fused gamma-carbolines | 细胞内治疗公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-110831941-A | Synthesis of substituted heterocycle fused gamma-carboline compound | 细胞内治疗公司 | 2020-02-21 | — | — | CN | disclosed |
| CN-103626766-B | With the synthesis of the heterocyclic fused γ carbolines of substitution | 细胞内治疗公司 | 2017-06-09 | — | — | CN | disclosed |
| CN-101796051-A | Synthesis of substituted heterocycle fused gamma-carbolines | INTRA CELLULAR THERAPIES INC | 2010-08-04 | — | — | CN | disclosed |
| EP-0154969-A2 | Piperazine derivatives and their acid addition salts | MITSUBISHI KASEI CORPORATION (JP) | 1985-09-18 | — | — | EP | disclosed |