SCHEMBL5356189

SCHEMBL5356189

Oc1cccc2c(Cl)c(Cl)ccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.56
AR P10275 1/20 0.49
CYP2A6 P11509 3/20 0.46
CYP3A4 P08684 2/20 0.46
MAPK1 P28482 1/20 0.46
IDO1 P14902 1/20 0.46
CYP1A2 P05177 4/20 0.44
HPGD P15428 2/20 0.44
HSD17B10 Q99714 2/20 0.44
MAPT P10636 2/20 0.44
APP P05067 1/20 0.44
THRB P10828 1/20 0.44
ALOX15 P16050 1/20 0.44
CASP1 P29466 1/20 0.44
SNCA P37840 1/20 0.44
RECQL P46063 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
ALDH1A1 P00352 2/20 0.44
KDM4E B2RXH2 2/20 0.44
LMNA P02545 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31434175 1.00 TSHR (0.56) TSHRARCYP2A6CYP3A4MAPK1
SCHEMBL19612295 0.82 IDO1 (0.46) TSHRARCYP2A6CYP3A4IDO1
SCHEMBL6109650 0.78 TRPV1 (0.45) TSHRCYP2A6CYP3A4IDO1CYP1A2
SCHEMBL30942487 0.78 IDO1 (0.42) TSHRARCYP3A4IDO1CYP1A2
SCHEMBL29932445 0.78 CYP2A6 (0.68) TSHRARCYP2A6CYP3A4CYP1A2
SCHEMBL4960152 0.78 CYP1A2 (0.68) TSHRCYP2A6CYP3A4IDO1CYP1A2
SCHEMBL20356025 0.78 CYP2A6 (0.68) TSHRARCYP2A6CYP3A4CYP1A2
SCHEMBL16107538 0.77 IDO1 (0.65) TSHRCYP3A4IDO1CYP1A2HPGD
SCHEMBL20356030 0.77 CYP2A6 (0.52) TSHRCYP2A6CYP3A4MAPK1CYP1A2
SCHEMBL29351230 0.77 IDO1 (0.73) TSHRCYP3A4IDO1CYP1A2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024147306-A1 AMIDE COMPOUND AND HARMFUL ARTHROPOD CONTROL COMPOSITION CONTAINING SAME 住友化学株式会社 2024-07-11 WO disclosed
US-20240109860-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2024-04-04 US disclosed
US-11827616-B2 Heterocyclic compounds as pesticides DISCOVERY PURCHASER CORPORATION (US) 2023-11-28 US disclosed
EP-3619196-B1 2-{[2-(PHENYLOXYMETHYL)PYRIDIN-5-YL]OXY}-ETHANAMIN-DERIVATIVES AND RELATED COMPOUNDS AS PESTICIDES E.G. FOR CROP PROTECTION BAYER CROPSCIENCE AG (DE) 2022-03-30 EP disclosed
EP-3619196-B1 2-{[2-(PHENYLOXYMETHYL)PYRIDIN-5-YL]OXY}-ETHANAMIN-DERIVATIVES AND RELATED COMPOUNDS AS PESTICIDES E.G. FOR CROP PROTECTION BAYER CROPSCIENCE AG (DE) 2022-03-30 EP disclosed
EP-3619196-A1 2-{[2-(PHENYLOXYMETHYL)PYRIDIN-5-YL]OXY}-ETHANAMIN-DERIVATIVES AND RELATED COMPOUNDS AS PEST-CONTROL AGENTS E.G. FOR THE PROTECTION OF PLANTS Bayer CropScience Aktiengesellschaft (DE) 2020-03-11 EP disclosed
CN-110869349-A 2- { [2- (phenoxymethyl) pyridin-5-yl ] oxy } ethanamine derivatives and related compounds as pest control agents, e.g. for protecting plants 拜耳作物科学股份公司 2020-03-06 CN disclosed
US-20200062729-A1 NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES DISCOVERY PURCHASER CORPORATION 2020-02-27 US disclosed
WO-2018202681-A1 USE OF DISUBSTITUTED BENZENES TO CONTROL INSECTICIDE-RESISTANT PESTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-11-08 WO disclosed
WO-2018202524-A1 2-{[2-(PHENYLOXYMETHYL)PYRIDIN-5-YL]OXY}-ETHANAMIN-DERIVATIVES AND RELATED COMPOUNDS AS PEST-CONTROL AGENTS E.G. FOR THE PROTECTION OF PLANTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-11-08 WO disclosed
WO-2018202525-A1 PHENOXYETHANAMINE DERIVATIVES FOR CONTROLLING PESTS BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2018-11-08 WO disclosed
US-7247756-B2 1,4-disubstituted benzenes as insecticides BAYER CROPSCIENCE AG (DE) 2007-07-24 US disclosed
WO-2006078619-A1 INSECTICIDAL HETEROCYCLIC 1,4-DISUBSTITUTED BENZENE N-OXIDES BAYER CROPSCIENCE AG (DE) 2006-07-27 WO disclosed
US-6753429-B2 FOR USE AS INSECTICIDES AGAINST A VARIETY OF INSECTS, INCLUDING LARVAE, SUCH AS TOBACCO BUDWORM FMC CORPORATION 2004-06-22 US disclosed
US-20030207894-A1 1,4-Disubstituted benzenes as insecticides BAYER CROPSCIENCE AG (DE) 2003-11-06 US disclosed
EP-1334083-A2 1,4-DISUBSTITUTED BENZENES AS INSECTICIDES FMC CORPORATION (US) 2003-08-13 EP disclosed
US-20020183342-A1 1,4-Disubstituted benzenes as insecticides BAYER CROPSCIENCE AG (DE) 2002-12-05 US disclosed
WO-2002017712-A2 DISUBSTITUTED BENZENES AS INSECTICIDES FMC CORPORATION (US) 2002-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030207894-A1 1,4-Disubstituted benzenes as insecticides DDT, CYP1B1, CYP4B1 TSHR 896/4885AR 822/4885CYP2A6 90/4885
US-11827616-B2 Heterocyclic compounds as pesticides DDT, CHRM1, ACHE TSHR 377/4885AR 1792/4885CYP2A6 516/4885
US-20240109860-A1 HETEROCYCLIC COMPOUNDS AS PESTICIDES DDT, CHRM1, ACHE TSHR 377/4885AR 1792/4885CYP2A6 516/4885
US-20020183342-A1 1,4-Disubstituted benzenes as insecticides DDT, CYP1B1, CYP4B1 TSHR 896/4885AR 822/4885CYP2A6 90/4885
US-20200062729-A1 NOVEL HETEROCYCLIC COMPOUNDS AS PESTICIDES CHRM1, DDT, ACHE TSHR 360/4885AR 1689/4885CYP2A6 812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.