SCHEMBL5356571

SCHEMBL5356571

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(N)(=O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.81

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.81
TGM2 P21980 1/20 0.75
KRAS P01116 11/20 0.70
HINT1 P49773 1/20 0.67
IMPDH2 P12268 5/20 0.67
FUT5 Q11128 1/20 0.67
IMPDH1 P20839 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8202050 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL18759049 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL20677331 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL9980018 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL20276926 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL13497991 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL21803790 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL21163348 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL18763818 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2
E626 SCHEMBL18785103 0.93 NT5E (0.83) NT5ETGM2KRASHINT1IMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4261217-A1 COMPOUND FOR RNA CAPPING AND APPLICATION OF COMPOUND Guangzhou Henovcom Bioscience Co., Ltd. (CN) 2023-10-18 EP disclosed
WO-2023159930-A1 COMPOUND FOR RNA CAPPING AND APPLICATION OF COMPOUND 广州市恒诺康医药科技有限公司 2023-08-31 WO disclosed
US-7217523-B2 Nucleoside phosphoramidates and nucleoside phosphoramidases REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2007-05-15 US disclosed
US-20060014193-A1 Nucleoside phosphoramidates and nucleoside phosphoramidases REGENTS OF THE UNIVERSITY OF MINNESOTA 2006-01-19 US disclosed