Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 4/20 | 0.41 |
| ▸ | CCR8 | P51685 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CCR5 | P51681 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1072939 | 0.83 | KDM4E (0.43) | CCR1CCR8KDM4EMAPTCCR5 | |
| SCHEMBL6131348 | 0.82 | CCR1 (0.42) | CCR1CCR8KDM4EMAPTCCR5 | |
| SCHEMBL7194074 | 0.78 | CCR1 (0.44) | CCR1CCR8KDM4EMAPTCCR5 | |
| SCHEMBL6292389 | 0.77 | CCR1 (0.43) | CCR1CCR8KDM4EMAPTCCR5 | |
| Hydrochloric Acid SCHEMBL3081477 | 0.76 | CCR1 (0.39) | CCR1CCR8KDM4EMAPTCCR5 | |
| SCHEMBL6055554 | 0.74 | CCR1 (0.40) | CCR1CCR8KDM4EMAPTCCR5 | |
| SCHEMBL5270900 | 0.71 | CCR1 (0.40) | CCR1CCR8KDM4EMAPTCCR5 | |
| Hydrochloric Acid SCHEMBL1072937 | 0.70 | MAPT (0.44) | CCR1CCR8KDM4EMAPTCCR5 | |
| SCHEMBL1282008 | 0.69 | CCR1 (0.75) | CCR1CCR8KDM4EMAPTCCR5 | |
| SCHEMBL30184687 | 0.69 | CCR1 (0.75) | CCR1CCR8KDM4EMAPTCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414405-A1 | CATALYST SYSTEM FOR THE POLYMERIZATION OF ALPHA-OLEFINS | Basell Polyolefine GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| US-20120010377-A1 | Catalyst System for the Polymerization of Alpha-Olefins | BASELL POLYOLEFINE GMBH (DE) | 2012-01-12 | — | — | US | disclosed |
| WO-2010112165-A1 | CATALYST SYSTEM FOR THE POLYMERIZATION OF ALPHA-OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2010-10-07 | — | — | WO | disclosed |