Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.75 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.57 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.52 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368424 | 0.91 | MDM2 (0.61) | MDM2CCNE1CDK2TLK2PDPK1 | |
| SCHEMBL5373793 | 0.87 | MAPT (0.66) | MDM2CCNE1CDK2PSEN1PSEN2 | |
| SCHEMBL5472567 | 0.86 | MDM2 (1.00) | MDM2CCNE1CDK2PSEN1PSEN2 | |
| SCHEMBL5472563 | 0.86 | MDM2 (1.00) | MDM2CCNE1CDK2PSEN1PSEN2 | |
| SCHEMBL6687938 | 0.85 | CSNK1D (0.71) | MDM2CCNE1CDK2TLK2PDPK1 | |
| SCHEMBL7136252 | 0.85 | NPC1 (0.72) | MDM2CCNE1CDK2MAPTMAPK1 | |
| SCHEMBL14448889 | 0.84 | MDM2 (1.00) | MDM2CCNE1CDK2MAPTMAPK1 | |
| SCHEMBL5469713 | 0.84 | MDM2 (1.00) | MDM2CCNE1CDK2MAPTMAPK1 | |
| SCHEMBL5469718 | 0.84 | MDM2 (1.00) | MDM2CCNE1CDK2MAPTMAPK1 | |
| SCHEMBL5358413 | 0.83 | RET (0.73) | CCNE1CDK2TLK2PDPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MDM2 888/4885CCNE1 884/4885CDK2 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.