Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.47 |
| ▸ | HTR2B | P41595 | 10/20 | 0.47 |
| ▸ | HTR2A | P28223 | 8/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358102 | 1.00 | HTR2C (0.47) | HTR2CHTR2BHTR2AHTR7HTR6 | |
| SCHEMBL4881120 | 0.82 | HTR2C (0.52) | HTR2CHTR2BHTR2AHTR7HTR6 | |
| SCHEMBL4884861 | 0.82 | HTR2C (0.52) | HTR2CHTR2BHTR2AHTR7HTR6 | |
| SCHEMBL4887832 | 0.82 | HTR2C (0.52) | HTR2CHTR2BHTR2AHTR7HTR6 | |
| SCHEMBL5509277 | 0.76 | ADRB1 (0.46) | HTR2CHTR2BHTR2AHTR7HTR6 | |
| SCHEMBL14837584 | 0.71 | ADRB1 (0.52) | HTR2CHTR2BHTR2AHTR6HTR1A | |
| SCHEMBL4914927 | 0.71 | HTR7 (0.73) | HTR2BHTR2AHTR7HTR6HTR1A | |
| SCHEMBL5509224 | 0.71 | ADRB1 (0.39) | HTR2CHTR2BHTR2AHTR6SLC6A2 | |
| Hydrochloric Acid SCHEMBL27828370 | 0.70 | HTR2C (0.46) | HTR2CHTR2BHTR2AHTR7HTR6 | |
| SCHEMBL28623340 | 0.70 | NSD2 (0.46) | HTR2CHTR2BHTR2AADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006065706-A9 | N-BIARYL AND N-ARYLHETEROARYL 2-SUBSTITUTED PIPERAZINE DERIVATIVES AS MODULATORS OF THE 5HT2C RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2007-07-26 | — | — | WO | disclosed |