Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | RAF1 | P04049 | 3/20 | 0.52 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687938 | 0.83 | CSNK1D (0.71) | MAPTRAF1MAP1LC3BGMNNLMNA | |
| SCHEMBL5366431 | 0.82 | RAF1 (0.61) | MAPTRAF1MAP1LC3BGMNNLMNA | |
| SCHEMBL5363455 | 0.82 | MAPT (0.58) | MAPTRAF1MAP1LC3BGMNNLMNA | |
| SCHEMBL5361494 | 0.82 | SYK (0.53) | MAPTGMNNLMNATP53CYP1A2 | |
| SCHEMBL5369940 | 0.82 | CSNK1D (0.46) | MAPTGMNNLMNATP53CYP1A2 | |
| SCHEMBL7132945 | 0.81 | MAPT (0.59) | MAPTRAF1MAP1LC3BGMNNLMNA | |
| SCHEMBL5361291 | 0.80 | MAPT (0.61) | MAPTRAF1MAP1LC3BGMNNLMNA | |
| SCHEMBL5368841 | 0.78 | CSNK1D (0.43) | MAPTRAF1MAP1LC3BGMNNLMNA | |
| SCHEMBL7136165 | 0.77 | MAPT (0.60) | MAPTRAF1MAP1LC3BGMNNLMNA | |
| SCHEMBL7136252 | 0.76 | NPC1 (0.72) | MAPTRAF1MAP1LC3BGMNNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MAPT 3048/4885RAF1 245/4885MAP1LC3B 1427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.