Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOGAT2 | Q3SYC2 | 3/20 | 0.51 |
| ▸ | MGAT2 | Q10469 | 5/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.41 |
| ▸ | MGAT1 | P26572 | 1/20 | 0.40 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358137 | 0.91 | MOGAT2 (0.52) | MOGAT2MGAT2LRRK2PSEN1PSEN2 | |
| SCHEMBL5358023 | 0.91 | MOGAT2 (0.52) | MOGAT2MGAT2LRRK2PSEN1PSEN2 | |
| SCHEMBL5366974 | 0.88 | MOGAT2 (0.51) | MOGAT2MGAT2LRRK2RAF1MDM2 | |
| SCHEMBL5362152 | 0.88 | MOGAT2 (0.52) | MOGAT2MGAT2LRRK2PSEN1PSEN2 | |
| SCHEMBL5361605 | 0.85 | MAP1LC3B (0.57) | MOGAT2MGAT2LRRK2PSEN1PSEN2 | |
| SCHEMBL5366412 | 0.85 | MOGAT2 (0.55) | MOGAT2MGAT2TLK2PRKDCNTRK1 | |
| SCHEMBL5363040 | 0.84 | MOGAT2 (0.52) | MOGAT2MGAT2LRRK2TLK2PRKDC | |
| SCHEMBL5369245 | 0.84 | MOGAT2 (0.52) | MOGAT2MGAT2LRRK2TLK2PRKDC | |
| SCHEMBL7133813 | 0.84 | MOGAT2 (0.52) | MOGAT2MGAT2LRRK2PSEN1PSEN2 | |
| SCHEMBL7138959 | 0.84 | MOGAT2 (0.54) | MOGAT2MGAT2LRRK2PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MOGAT2 1159/4885MGAT2 4714/4885LRRK2 289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.