Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.53 |
| ▸ | RET | P07949 | 7/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.39 |
| ▸ | FLT3 | P36888 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.36 |
| ▸ | STK3 | Q13188 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5367053 | 0.83 | PDGFRB (0.50) | KDRRETPDGFRBFGFR1ALK | |
| SCHEMBL5366277 | 0.81 | RET (0.64) | KDRRETPDGFRBFGFR1ALK | |
| SCHEMBL7138166 | 0.79 | KDR (0.44) | KDRRETPDGFRBFGFR1ALK | |
| SCHEMBL5368918 | 0.77 | PDGFRB (0.66) | KDRRETPDGFRBFGFR1ALK | |
| SCHEMBL7134014 | 0.77 | RET (0.48) | RETPDGFRBPLK4CDK1EGFR | |
| SCHEMBL5377025 | 0.77 | RET (0.54) | KDRRETPDGFRBEGFR | |
| SCHEMBL5365192 | 0.77 | RET (0.40) | KDRRETPDGFRBFGFR1ALK | |
| SCHEMBL5999769 | 0.76 | KDR (0.82) | KDRRETPDGFRBFGFR1ALK | |
| SCHEMBL5999773 | 0.76 | KDR (0.82) | KDRRETPDGFRBFGFR1ALK | |
| SCHEMBL7132935 | 0.75 | MEN1 (0.56) | KDRRETPDGFRBFLT3PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | KDR 239/4885RET 283/4885PDGFRB 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.