Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.34 |
| ▸ | RET | P07949 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.30 |
| ▸ | CSF1R | P07333 | 2/20 | 0.30 |
| ▸ | SRC | P12931 | 2/20 | 0.30 |
| ▸ | FLT1 | P17948 | 2/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.30 |
| ▸ | FLT4 | P35916 | 2/20 | 0.30 |
| ▸ | FLT3 | P36888 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137922 | 0.83 | KDR (0.42) | KDRPDGFRBFGFR1RETALK | |
| SCHEMBL7133834 | 0.82 | RET (0.52) | KDRPDGFRBFGFR1RETALK | |
| SCHEMBL5365604 | 0.79 | KDR (0.47) | KDRPDGFRBFGFR1RETALDH1A1 | |
| SCHEMBL5358801 | 0.79 | KDR (0.53) | KDRPDGFRBFGFR1RETALK | |
| SCHEMBL7137031 | 0.78 | PDGFRB (0.33) | KDRPDGFRBFGFR1RETALDH1A1 | |
| SCHEMBL7136788 | 0.77 | PDGFRB (0.58) | KDRPDGFRBFGFR1RETALDH1A1 | |
| SCHEMBL7138182 | 0.76 | KMT2A (0.42) | RETALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL7136101 | 0.76 | RET (0.44) | RETKMT2AMEN1NPC1 | |
| SCHEMBL7138862 | 0.76 | MAPT (0.47) | RETALDH1A1ALDH2ALDH3A1MAPK1 | |
| SCHEMBL7138169 | 0.75 | POLB (0.42) | KDRRETALDH1A1ALDH2ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |