Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 20/20 | 0.71 |
| ▸ | RXRB | P28702 | 11/20 | 0.71 |
| ▸ | RXRG | P48443 | 11/20 | 0.71 |
| ▸ | RARA | P10276 | 3/20 | 0.71 |
| ▸ | RARB | P10826 | 3/20 | 0.71 |
| ▸ | RARG | P13631 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28646163 | 0.88 | RXRA (0.59) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7218238 | 0.86 | RXRA (0.73) | RXRARXRBRXRGRARARARB | |
| SCHEMBL3298635 | 0.85 | RXRA (0.61) | RXRARXRBRXRGRARARARB | |
| SCHEMBL2591205 | 0.84 | RXRA (0.78) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6901726 | 0.84 | RXRA (0.69) | RXRARXRBRXRGRARARARB | |
| SCHEMBL30054740 | 0.83 | RXRA (1.00) | RXRARXRBRXRGRARARARB | |
| SCHEMBL726140 | 0.83 | RXRA (1.00) | RXRARXRBRXRGRARARARB | |
| SCHEMBL16926898 | 0.83 | RXRA (0.83) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7872153 | 0.83 | RXRA (0.59) | RXRARXRBRXRGRARARARB | |
| SCHEMBL14212719 | 0.83 | RXRA (0.76) | RXRARXRBRXRGRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259187-B2 | Tropolone derivatives | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2007-08-21 | — | — | US | disclosed |
| US-20040082550-A1 | Tropolone derivative | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2004-04-29 | — | — | US | disclosed |
| EP-1357104-A1 | TROPOLONE DERIVATIVE | Research Foundation Itsuu Laboratory (JP) | 2003-10-29 | — | — | EP | disclosed |
| US-6326510-B1 | SKIN DISORDERS; ANTICANCER AGENTS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 2001-12-04 | — | — | US | disclosed |
| US-5231113-A | Skin disorders, immunology or wound healing agents | ALLERGAN, INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0337689-B1 | TETRALIN ESTERS OF PHENOLS OR BENZOIC ACIDS HAVING RETINOID LIKE ACTIVITY | ALLERGAN, INC (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5130335-A | Treatment of skin disorders | ALLERGAN, INC. (US) | 1992-07-14 | — | — | US | disclosed |
| EP-0337689-A1 | Tetralin esters of phenols or benzoic acids having retinoid like activity | ALLERGAN, INC (US) | 1989-10-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082550-A1 | Tropolone derivative | NR5A2, NR0B1, MTNR1A | RXRA 10/4885RXRB 18/4885RXRG 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.