Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5395197 | 0.89 | KMT2A (0.41) | KMT2AMEN1GBA1ALDH1A1HSD17B10 | |
| SCHEMBL5361146 | 0.84 | GLA (0.41) | KMT2AMEN1ALDH1A1LMNATSHR | |
| SCHEMBL2682607 | 0.84 | GLA (0.41) | KMT2AMEN1ALDH1A1LMNATSHR | |
| SCHEMBL5349386 | 0.83 | MEN1 (0.36) | KMT2AMEN1GBA1ALDH1A1HSD17B10 | |
| SCHEMBL2683681 | 0.74 | GLA (0.43) | KMT2AMEN1ALDH1A1LMNATSHR | |
| SCHEMBL2682454 | 0.72 | GLA (0.41) | KMT2AMEN1ALDH1A1LMNATSHR | |
| SCHEMBL5399837 | 0.72 | GLA (0.41) | KMT2AMEN1ALDH1A1LMNATSHR | |
| SCHEMBL2683217 | 0.72 | CTSG (0.37) | KMT2AMEN1GBA1ALDH1A1LMNA | |
| SCHEMBL2683687 | 0.72 | CTSG (0.37) | KMT2AMEN1GBA1ALDH1A1LMNA | |
| SCHEMBL3906119 | 0.69 | LMNA (0.43) | KMT2AMEN1ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863763-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | Speedel Experimenta AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103275-A1 | 3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |