CTSG — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL438416	0.51	9/20
SCHEMBL151557	0.53	8/20
SCHEMBL461153	0.61	7/20
SCHEMBL912869	0.57	7/20
SCHEMBL436836	0.53	7/20
SCHEMBL405682	0.51	7/20
SCHEMBL869119	0.48	7/20
SCHEMBL775761	0.41	7/20
SCHEMBL407974	0.47	6/20
SCHEMBL868062	0.46	6/20
SCHEMBL813194	0.39	6/20
SCHEMBL410155	0.57	5/20
SCHEMBL486105	0.56	5/20
SCHEMBL127114	0.55	5/20
SCHEMBL409062	0.54	5/20
SCHEMBL409905	0.53	5/20
SCHEMBL670389	0.51	5/20
SCHEMBL407877	0.50	5/20
SCHEMBL405429	0.46	5/20
SCHEMBL405430	0.46	5/20

Clinical trials — most relevant to CTSG by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Imatinib in KIT-negative Systemic Mastocytosis	PHASE4	COMPLETED
Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation	PHASE4	COMPLETED
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19	PHASE2/PHASE3	UNKNOWN
A Pilot Study of Use of Calcium Channel Blocker to Decrease Inflammation and Pain in Hereditary Pancreatitis	PHASE1/PHASE2	COMPLETED
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma	PHASE1	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis	nan	COMPLETED
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Synovial Fluid Bank From Arthritic Patients	nan	RECRUITING
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD	nan	NOT_YET_RECRUITING
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome	nan	RECRUITING
Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study	nan	NOT_YET_RECRUITING
Hematological Markers in Idiopathic Carpal Tunnel Syndrome	nan	COMPLETED
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients	nan	RECRUITING
Salivary Biomarkers for Sjögren's Syndrome Detection	nan	COMPLETED
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Validating a New Severity Score System for Adults With Type 1 Gaucher Disease (GD1)	nan	COMPLETED
Proteases in Patients With Prostate Cancer That Has Spread to the Bone	nan	COMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Ultrasound Measures and Clinical Outcomes in Healthy Individuals, Mild and Moderate Carpal Tunnel Syndrome Patients	nan	COMPLETED
Multimodal Approach of Electrotherapy Versus Nerve Flossing Technique in Patient With Carpal Tunnel Syndrome	nan	UNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery	nan	RECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
Markers in Acute Pancreatitis-1	nan	COMPLETED
Genetic Studies of Lysosomal Storage Disorders	nan	ENROLLING_BY_INVITATION
Neutral Endopeptidase for Early Detection of Acute Kidney Injury After Cardiac Surgery	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CTSG binder may also engage these)

Protein	Name	Similarity
P17977	—	0.990	P17977 →
P28293	—	0.985	P28293 →
P56435	—	0.974	P56435 →
Q9H2R5	—	0.973	Q9H2R5 →
CMA1	Chymase	0.973	landscape →
P80219	—	0.972	P80219 →
P79204	—	0.972	P79204 →
PRTN3	Myeloblastin	0.972	landscape →
P21842	—	0.970	P21842 →
O46683	—	0.969	O46683 →
Q7JIG6	—	0.969	Q7JIG6 →
P80931	—	0.969	P80931 →
P52195	—	0.967	P52195 →
P50341	—	0.967	P50341 →
Q61096	—	0.966	Q61096 →
Q9UKR0	—	0.964	Q9UKR0 →
P97592	—	0.963	P97592 →
Q8CGR5	—	0.963	Q8CGR5 →
GZMB	Granzyme B	0.962	landscape →
A7WPL7	—	0.962	A7WPL7 →
P50339	—	0.962	P50339 →
P20718	—	0.962	P20718 →
Q3UP87	—	0.960	Q3UP87 →
KLK6	Kallikrein-6	0.960	landscape →
P21844	—	0.959	P21844 →
KLK5	Kallikrein-5	0.959	landscape →
KLK14	Kallikrein-14	0.958	landscape →
P09650	—	0.958	P09650 →
P21812	—	0.958	P21812 →
P51779	—	0.956	P51779 →