Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | CCR1 | P32246 | 3/20 | 0.55 |
| ▸ | CCR5 | P51681 | 3/20 | 0.55 |
| ▸ | CCR8 | P51685 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | ALPG | P10696 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577722 | 0.81 | CCR1 (0.59) | KDM4ELMNAL3MBTL1CCR1CCR8 | |
| SCHEMBL14350440 | 0.81 | KDM4E (0.50) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL1034731 | 0.79 | DUSP10 (0.54) | KDM4ELMNAL3MBTL1TP53TDP1 | |
| SCHEMBL30644405 | 0.79 | LMNA (0.44) | KDM4ELMNAL3MBTL1CCR1CCR8 | |
| SCHEMBL26644234 | 0.79 | LMNA (0.44) | KDM4ELMNAL3MBTL1CCR1CCR8 | |
| SCHEMBL28286847 | 0.79 | LMNA (0.44) | KDM4ELMNAL3MBTL1TDP1MAPK1 | |
| SCHEMBL18210579 | 0.78 | LMNA (0.46) | KDM4ELMNAL3MBTL1TDP1HTT | |
| SCHEMBL1181563 | 0.77 | KDM4E (0.88) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL9864937 | 0.75 | HSP90AA1 (0.48) | KDM4ELMNAL3MBTL1CCR1CCR8 | |
| SCHEMBL5846199 | 0.75 | KDM4E (0.52) | KDM4ELMNAL3MBTL1CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106659721-A | Process for the preparation of a medicament | 基因泰克公司 | 2017-05-10 | — | — | CN | disclosed |
| US-9579325-B2 | Modulators of TNF-α signaling | GENZYME CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
| US-20150126512-A1 | Modulators Of TNF-Alpha Signaling | GENZYME CORPORATION (US) | 2015-05-07 | — | — | US | disclosed |
| US-8921547-B2 | Modulators of TNF-α signaling | GENZYME CORPORATION (US) | 2014-12-30 | — | — | US | disclosed |
| US-20130310388-A1 | Modulators of TNF-Alpha Signaling | GENZYME CORPORATION (US) | 2013-11-21 | — | — | US | disclosed |
| US-8518999-B2 | Modulators of TNF-αsignaling | GENZYME CORPORATION (US) | 2013-08-27 | — | — | US | disclosed |
| US-7238697-B2 | Pyridylpyrimidines for use as pesticides | BAYER CROPSCIENCE AG (DE) | 2007-07-03 | — | — | US | disclosed |
| US-7238697-B2 | Pyridylpyrimidines for use as pesticides | BAYER CROPSCIENCE AG (DE) | 2007-07-03 | — | — | US | disclosed |
| US-7238697-B2 | Pyridylpyrimidines for use as pesticides | BAYER CROPSCIENCE AG (DE) | 2007-07-03 | — | — | US | disclosed |
| US-20060173010-A1 | Modulators of TNF-alpha signaling | GENZYME | 2006-08-03 | — | — | US | disclosed |
| US-7034031-B2 | Modulators of TNF-α signaling | GENZYME CORPORATION (US) | 2006-04-25 | — | — | US | disclosed |
| US-6969728-B2 | Antiinflammatory agents | GENZYME CORPORATION (US) | 2005-11-29 | — | — | US | disclosed |
| US-20040171617-A1 | treatment for disorders and diseases, such as chronic inflammation, tissue breakdown and cancer | GENZYME CORPORATION | 2004-09-02 | — | — | US | disclosed |
| US-20040077641-A1 | Pyridyl pyrimidines for use as pesticides | BAYER CROPSCIENCE AG (DE) | 2004-04-22 | — | — | US | disclosed |
| EP-1367893-A1 | PYRIDYL PYRIMIDINES FOR USE AS PESTICIDES | Bayer CropScience AG (DE) | 2003-12-10 | — | — | EP | disclosed |
| EP-1294699-A2 | MODULATORS OF TNF- ALPHA SIGNALLING | GENZYME CORPORATION (US) | 2003-03-26 | — | — | EP | disclosed |
| WO-2002067684-A1 | PYRIDYL PYRIMIDINES FOR USE AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2002-09-06 | — | — | WO | disclosed |
| US-20020119988-A1 | Antiinflammatory agents | GENZYME CORPORATION | 2002-08-29 | — | — | US | disclosed |
| WO-2001087849-A2 | MODULATORS OF TNF- ALPHA SIGNALING | GENZYME CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020119988-A1 | Antiinflammatory agents | TNF, TNFRSF1A, CD40 | KDM4E 4319/4885LMNA 3290/4885L3MBTL1 4750/4885 |
| US-20040171617-A1 | treatment for disorders and diseases, such as chronic inflammation, tissue breakdown and cancer | TNF, TNFRSF1A, CD40 | KDM4E 3837/4885LMNA 2332/4885L3MBTL1 3443/4885 |
| US-20150126512-A1 | Modulators Of TNF-Alpha Signaling | TNF, TNFRSF1A, TNFRSF9 | KDM4E 4252/4885LMNA 2549/4885L3MBTL1 4543/4885 |
| US-20060173010-A1 | Modulators of TNF-alpha signaling | TNF, TNFRSF1A, TNFRSF9 | KDM4E 4252/4885LMNA 2549/4885L3MBTL1 4543/4885 |
| US-20040077641-A1 | Pyridyl pyrimidines for use as pesticides | PNPO, P2RX6, P2RX1 | KDM4E 2707/4885LMNA 3538/4885L3MBTL1 937/4885 |
| US-20130310388-A1 | Modulators of TNF-Alpha Signaling | TNF, TNFRSF1A, TNFRSF9 | KDM4E 4252/4885LMNA 2549/4885L3MBTL1 4543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.