Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13133556 | 0.81 | MAPT (0.58) | HSP90AA1HSP90AB1LMNAKDM4EHTT | |
| SCHEMBL9864818 | 0.77 | LMNA (0.46) | HSP90AB1LMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL7526568 | 0.75 | ALDH1A1 (0.56) | HSP90AA1HSP90AB1LMNAKDM4EHTT | |
| SCHEMBL5361682 | 0.75 | KDM4E (0.55) | HSP90AA1LMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL14267870 | 0.74 | ADORA2A (0.59) | HSP90AA1HSP90AB1LMNAKDM4ENPSR1 | |
| SCHEMBL7525473 | 0.74 | MAPT (0.51) | HSP90AA1HSP90AB1LMNAKDM4EHTT | |
| SCHEMBL5593348 | 0.74 | MAPT (0.51) | HSP90AA1HSP90AB1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL1445103 | 0.74 | MAPT (0.51) | HSP90AA1HSP90AB1LMNAKDM4EHTT | |
| SCHEMBL29502715 | 0.74 | ADORA2A (0.59) | HSP90AA1HSP90AB1LMNAKDM4ENPSR1 | |
| SCHEMBL7521036 | 0.74 | KDM4E (0.56) | HSP90AA1HSP90AB1LMNAKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118451068-A | Tri-fused ring derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-08-06 | — | — | CN | disclosed |
| US-5003077-A | Having a cycloheptimidazole nucleus; photostability; methine bond having an auxochrome | FUJI PHOTO FILM CO., LTD. (JP) | 1991-03-26 | — | — | US | disclosed |
| US-4900648-A | RECORDING, ERASING USING LASER BEAM, METHINE DYE | FUJI PHOTO FILM CO., LTD. (JP) | 1990-02-13 | — | — | US | disclosed |
| US-4814265-A | CONTAINING METHANE DYE | FUJI PHOTO FILM CO., LTD. (JP) | 1989-03-21 | — | — | US | disclosed |
| US-4351832-A | 2-(Piperazinyl)-4-pyrimidinamines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-28 | — | — | US | disclosed |
| US-4333937-A | 2-(Piperazinyl)-4-pyrimioinamines | AMERICAN HOME PRODUCTS CORP. (US) | 1982-06-08 | — | — | US | disclosed |
| EP-0039190-A1 | 2-(1-Piperazinyl)-4-pyrimidinamines and related compounds | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-11-04 | — | — | EP | disclosed |
| WO-1981003022-A1 | 2-(1-PIPERAZINYL)-4-PYRIMIDINAMINES | AMERICAN HOME PROD (US) | 1981-10-29 | — | — | WO | disclosed |
| EP-0056027-A1 | 2-(1-PIPERAZINYL)-4-PYRIMIDINAMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-10-29 | — | — | EP | disclosed |