SCHEMBL5362341

SCHEMBL5362341

CCCCCCCCCCCCCCCC(=O)OC[C@H]1O[C@@H](n2ccc(NC(=O)[C@@H](N)CCCCN)nc2=O)C[C@@H]1O

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PLA2G1B P04054 1/20 0.42
ATG4B Q9Y4P1 1/20 0.42
DNMT1 P26358 3/20 0.38
POLB P06746 2/20 0.38
NT5E P21589 1/20 0.36
DNMT3B Q9UBC3 1/20 0.36
P2RY2 P41231 4/20 0.36
P2RY4 P51582 3/20 0.35
P2RY6 Q15077 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5361622 0.84 SIRT1 (0.40) PLA2G1BATG4BP2RY2
SCHEMBL5360960 0.84 PLA2G1B (0.36) PLA2G1BATG4BDNMT1POLBDNMT3B
SCHEMBL5357575 0.84 PLA2G1B (0.36) PLA2G1BATG4BDNMT1POLBDNMT3B
SCHEMBL2984540 0.80 POLB (0.56) PLA2G1BATG4BDNMT1POLBP2RY2
SCHEMBL5369313 0.80 POLB (0.56) PLA2G1BATG4BDNMT1POLBP2RY2
SCHEMBL29703014 0.77 POLB (0.47) DNMT1POLBDNMT3B
SCHEMBL2728382 0.74 POLB (0.49) PLA2G1BATG4BDNMT1POLB
SCHEMBL9854228 0.74 DNMT1 (0.45) PLA2G1BATG4BDNMT1POLBDNMT3B
SCHEMBL30238601 0.74 PLA2G1B (0.52) PLA2G1BATG4BPOLBNT5EP2RY2
SCHEMBL30239103 0.73 POLB (0.50) DNMT1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7169765-B1 Acyl deoxyribonucleoside derivatives and uses thereof WELLSTAT THERAPEUTICS CORPORATION (US) 2007-01-30 US disclosed
EP-0712629-B1 Acyl deoxyribonucleoside derivatives and uses thereof WELLSTAT THERAPEUTICS CORP (US) 2003-06-18 EP disclosed
US-6348451-B1 WOUND HEALING AGENTS FOR ANIMALS PRO-NEURON, INC. 2002-02-19 US disclosed
US-6306834-B1 METHODS OF TREATING OR PREVENTING RADIATION, MUTAGEN AND SUNLIGHT-INDUCED BIOLOGICAL DAMAGE, METHODS FOR IMPROVING WOUND HEALING AND TISSUE REPAIR, COMPRISING ADMINISTERING THE COMPOSITIONS OF THE PRESENT INVENTION TO AN ANIMAL. PRO-NEURON, INC. 2001-10-23 US disclosed
US-6297222-B1 TREATING OR PREVENTING RADIATION, MUTAGEN AND SUNLIGHT-INDUCED BIOLOGICAL DAMAGE, AND METHODS FOR IMPROVING WOUND HEALING AND TISSUE REPAIR PRO-NEURON, INC. 2001-10-02 US disclosed
US-6103701-A ADMINISTERING COMPOSITIONS COMPRISING ACYL DERIVATIVES OF 2'-DEOXYRIBONUCLEOSIDES; FOR IMPROVING WOUND HEALING AND TISSUE REPAIR VON BORSTEL REID WARREN (US) 2000-08-15 US disclosed
US-6020322-A Acyl deoxyribonucleoside derivatives and uses thereof PRO-NEURON, INC. (US) 2000-02-01 US disclosed
EP-0355131-B1 ACYL DEOXYRIBONUCLEOSIDE DERIVATIVES AND USES THEREOF PRO NEURON INC (US) 1996-09-04 EP disclosed
EP-0712629-A1 Acyl deoxyribonucleoside derivatives and uses thereof PRO-NEURON, INC. (US) 1996-05-22 EP disclosed
EP-0355131-A1 ACYL DEOXYRIBONUCLEOSIDE DERIVATIVES AND USES THEREOF PRO-NEURON, INC. (US) 1990-02-28 EP disclosed