Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 10/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359245 | 0.90 | TAAR1 (0.46) | TAAR1TBXAS1TERTADRA2AADRA2B | |
| SCHEMBL2035642 | 0.82 | TAAR1 (0.56) | TAAR1ADRA2AADRA2BADRA2CCYP2D6 | |
| SCHEMBL9777191 | 0.77 | TBXAS1 (0.60) | TAAR1TBXAS1TERTADRA2AADRA2B | |
| SCHEMBL3450884 | 0.77 | HTR2A (0.30) | — | |
| SCHEMBL8958092 | 0.75 | TAAR1 (0.65) | TAAR1TBXAS1TERTCYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL3645890 | 0.73 | TAAR1 (0.62) | TAAR1TBXAS1TERTADRA2AADRA2B | |
| SCHEMBL3431746 | 0.73 | TBXAS1 (0.66) | TAAR1TBXAS1TERTADRA2AADRA2B | |
| SCHEMBL2528409 | 0.73 | MAOA (0.31) | — | |
| SCHEMBL5362554 | 0.72 | TBXAS1 (0.45) | TAAR1TBXAS1TERTCYP2D6TSHR | |
| SCHEMBL15121693 | 0.71 | TAAR1 (0.65) | TAAR1TBXAS1TERTCYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135417-A1 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135417-A1 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-11-29 | — | — | WO | disclosed |