SCHEMBL5362841

SCHEMBL5362841

CC(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1OC(C)=O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.51
ENPP1 P22413 2/20 0.51
P2RY1 P47900 2/20 0.51
STING1 Q86WV6 1/20 0.47
ADA P00813 1/20 0.47
DNPH1 O43598 1/20 0.46
PRKAB2 O43741 1/20 0.46
TRPM2 O94759 1/20 0.46
LDHA P00338 1/20 0.46
ADRB2 P07550 1/20 0.46
FBP1 P09467 1/20 0.46
SRC P12931 1/20 0.46
ADORA1 P30542 1/20 0.46
P2RY2 P41231 1/20 0.46
PRKAG1 P54619 1/20 0.46
PRKAA2 P54646 1/20 0.46
PDE4D Q08499 1/20 0.46
KCNH2 Q12809 1/20 0.46
PRKAA1 Q13131 1/20 0.46
PDE3A Q14432 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5361698 1.00 POLB (0.51) POLBENPP1P2RY1STING1ADA
SCHEMBL9233212 0.95 POLB (0.59) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL9466645 0.90 ADA (0.53) POLBENPP1P2RY1STING1ADA
SCHEMBL9466654 0.90 ADA (0.53) POLBENPP1P2RY1STING1ADA
SCHEMBL6536401 0.89 PRKAB2 (0.46) POLBENPP1P2RY1PRKAB2PRKAG1
SCHEMBL30586400 0.88 PRKAB2 (0.43) POLBENPP1P2RY1PRKAB2PRKAG1
SCHEMBL30586385 0.88 HIF1A (0.45) POLBENPP1P2RY1PRKAB2PRKAG1
SCHEMBL8623380 0.88 POLB (0.65) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL3259692 0.88 POLB (0.65) POLBENPP1P2RY1DNPH1PRKAB2
SCHEMBL1797403 0.88 POLB (0.48) POLBENPP1P2RY1STING1ADA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5001093-A None JP disclosed
US-7169765-B1 Acyl deoxyribonucleoside derivatives and uses thereof WELLSTAT THERAPEUTICS CORPORATION (US) 2007-01-30 US disclosed
EP-0712629-B1 Acyl deoxyribonucleoside derivatives and uses thereof WELLSTAT THERAPEUTICS CORP (US) 2003-06-18 EP disclosed
US-6348451-B1 WOUND HEALING AGENTS FOR ANIMALS PRO-NEURON, INC. 2002-02-19 US disclosed
US-6306834-B1 METHODS OF TREATING OR PREVENTING RADIATION, MUTAGEN AND SUNLIGHT-INDUCED BIOLOGICAL DAMAGE, METHODS FOR IMPROVING WOUND HEALING AND TISSUE REPAIR, COMPRISING ADMINISTERING THE COMPOSITIONS OF THE PRESENT INVENTION TO AN ANIMAL. PRO-NEURON, INC. 2001-10-23 US disclosed
US-6297222-B1 TREATING OR PREVENTING RADIATION, MUTAGEN AND SUNLIGHT-INDUCED BIOLOGICAL DAMAGE, AND METHODS FOR IMPROVING WOUND HEALING AND TISSUE REPAIR PRO-NEURON, INC. 2001-10-02 US disclosed
US-5756704-A Nucleosides and nucleoside derivatives containing enzymatically cleavable protecting groups BOEHRINGER MANNHEIM GMBH (DE) 1998-05-26 US disclosed
US-5677441-A Nucleosides, nucleotides and oligonucleotides containing enzymatically cleavable protecting groups BOEHRINGER MANNHEIM GMBH (DE) 1997-10-14 US disclosed
EP-0355131-B1 ACYL DEOXYRIBONUCLEOSIDE DERIVATIVES AND USES THEREOF PRO NEURON INC (US) 1996-09-04 EP disclosed
EP-0712629-A1 Acyl deoxyribonucleoside derivatives and uses thereof PRO-NEURON, INC. (US) 1996-05-22 EP disclosed
EP-0649855-A1 Use of nucleosides and nucleoside derivatives with enzymatically cleavable protecting groupes in the synthesis of oligonucleotiden Roche Diagnostics GmbH (DE) 1995-04-26 EP disclosed
JP-H051093-A METHOD FOR SUCCINYLATING NUCLEOSIDE YAMASA SHOYU CO LTD 1993-01-08 JP disclosed
EP-0355131-A1 ACYL DEOXYRIBONUCLEOSIDE DERIVATIVES AND USES THEREOF PRO-NEURON, INC. (US) 1990-02-28 EP disclosed