Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.56 |
| ▸ | PDE4A | P27815 | 8/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7938329 | 0.94 | GAA (0.60) | PDE4BPDE4APDE4CPDE4DGAA | |
| SCHEMBL5351545 | 0.88 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL5351550 | 0.88 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7379306 | 0.88 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7379302 | 0.88 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7379304 | 0.88 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7435309 | 0.85 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDE3A | |
| SCHEMBL5363123 | 0.84 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DGAA | |
| SCHEMBL5363118 | 0.84 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DGAA | |
| SCHEMBL7416129 | 0.84 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542795-B1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5547979-A | TNF inhibition | SMITHKLINE BEECHAM (US) | 1996-08-20 | — | — | US | disclosed |
| US-5420154-A | ADMINISTERING A 2-PYRROLIDINONE DERIVATIVE TO AN ANIMAL SUFFERING FROM A TUMOR NECROSIS FACTOR MEDIATED DISEASE | SMITHKLINE BEECHAM CORP. (US) | 1995-05-30 | — | — | US | disclosed |
| EP-0584208-A4 | — | — | 1994-03-23 | — | — | EP | disclosed |
| EP-0584208-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-03-02 | — | — | EP | disclosed |
| EP-0542795-A1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-05-26 | — | — | EP | disclosed |
| WO-1992019594-A1 | PYRROLIDINONES | SMITHKLINE BEECHAM CORPORATION (US) | 1992-11-12 | — | — | WO | disclosed |
| WO-1992002220-A1 | TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-20 | — | — | WO | disclosed |