Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5370156 | 0.87 | HDAC6 (0.51) | HDAC6FAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL5362714 | 0.87 | HDAC6 (0.59) | HDAC6FAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL14425186 | 0.85 | HDAC6 (0.51) | HDAC6FAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL14425184 | 0.85 | HDAC6 (0.52) | HDAC6FAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL5368614 | 0.84 | HDAC6 (0.55) | HDAC6FAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL14425181 | 0.80 | FAAH (0.49) | HDAC6FAAHSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14425179 | 0.80 | NAMPT (0.53) | HDAC6FAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL5359104 | 0.80 | KDM4E (0.48) | HDAC6FAAHCYP2C19CKS1BSKP1 | |
| SCHEMBL14425178 | 0.78 | FAAH (0.49) | HDAC6FAAHHDAC3HDAC4HDAC1 | |
| SCHEMBL14425182 | 0.78 | FAAH (0.49) | HDAC6FAAHALDH1A1LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |
| US-7259157-B2 | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists | MERCK & CO., INC. (US) | 2007-08-21 | — | — | US | disclosed |