Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31199115 | 1.00 | DRD2 (0.43) | DRD2DRD3CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL32668882 | 1.00 | DRD2 (0.43) | DRD2DRD3CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL6702184 | 0.85 | HTR2A (0.38) | DRD2DRD3KEAP1SMN1; SMN2HTR2A | |
| SCHEMBL7219591 | 0.84 | ACHE (0.48) | — | |
| SCHEMBL9913091 | 0.75 | PRCP (0.52) | CYP2C9CYP2C19MAPTNPSR1MEN1 | |
| SCHEMBL30952112 | 0.75 | PRCP (0.52) | CYP2C9CYP2C19MAPTNPSR1MEN1 | |
| SCHEMBL14933933 | 0.75 | PRCP (0.52) | CYP2C9CYP2C19MAPTNPSR1MEN1 | |
| SCHEMBL8905140 | 0.74 | CYP2C9 (0.42) | DRD3CYP2C9CYP2C19CYP1A2MAPT | |
| SCHEMBL30109036 | 0.73 | HTR2A (0.46) | KMT2AHTR2AHRH1HTR2C | |
| SCHEMBL5365272 | 0.73 | HTR2A (0.59) | DRD2HTR2AHRH1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0496306-B1 | Process for the preparation of 3-amino-9,13b-dihydro-1H-dibenz-[c,f]imidazo[1,5-a]azepine hydrochloride | BOEHRINGER INGELHEIM KG (DE) | 1995-09-13 | — | — | EP | claimed |
| EP-0431968-B1 | Oxetane derivatives, their preparation and their use as anti-fungal or fungicidal agents | SANKYO CO (JP) | 1995-03-15 | — | — | EP | claimed |
| US-5312916-A | Process for preparing 3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine-hydrochloride | BOEHRINGER INGELHEIM KG (DE) | 1994-05-17 | — | — | US | claimed |
| EP-0496306-A1 | Process for the preparation of 3-amino-9,13b-dihydro-1H-dibenz-[c,f]imidazo[1,5-a]azepine hydrochloride | BOEHRINGER INGELHEIM KG (DE) | 1992-07-29 | — | — | EP | claimed |
| CN-114835712-A | Synthesis method of epinastine | 重庆恩联生物科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-114835712-A | Synthesis method of epinastine | 重庆恩联生物科技有限公司 | 2022-08-02 | — | — | CN | disclosed |
| US-7196193-B2 | Method for preparing 6-aminomethyl-6, 11-dihydro-5h-dibenz[b,e]azepine | KONICA MINOLTA CHEMICAL CO., LTD. (JP) | 2007-03-27 | — | — | US | disclosed |
| EP-1496051-B1 | METHOD FOR PREPARING 6-AMINOMETHYL-6,11-DIHYDRO-5H-DIBENZ(B,E)AZEPINE | KONICA MINOLTA CHEMICAL CO LTD (JP) | 2006-11-29 | — | — | EP | disclosed |
| US-20050209215-A1 | Method for preparing 6-aminomethyl-6,11-dihydro-5h-dibenz[b,e]azepine | KONICA MINOLTA CHEMICAL CO., LTD. (JP) | 2005-09-22 | — | — | US | disclosed |
| EP-1496051-A1 | METHOD FOR PREPARING 6-AMINOMETHYL-6,11-DIHYDRO-5H-DIBENZ(B,E)AZEPINE | Konica Minolta Chemical Co., Ltd. (JP) | 2005-01-12 | — | — | EP | disclosed |
| EP-1273583-A1 | Process for reducing 2-(11H-dibenz(b,e)azepin-6-ylmethyl)-1H-isoindole-1,3(2H)-dione | ICROM S.p.A. (IT) | 2003-01-08 | — | — | EP | disclosed |
| EP-0469460-B1 | Herbicidal sulphonylureas, method for their preparation and intermediates | BASF AG (DE) | 1995-10-18 | — | — | EP | disclosed |
| EP-0446743-B1 | Herbicidal sulfonylureas, process for their preparation and intermediates | BASF AG (DE) | 1995-08-02 | — | — | EP | disclosed |
| EP-0600967-B1 | HERBICIDAL SULPHONYL UREAS, PROCESS AND INTERMEDIATES FOR PRODUCING THE SAME | BASF AG (DE) | 1995-04-19 | — | — | EP | disclosed |
| US-5312916-A | Process for preparing 3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine-hydrochloride | BOEHRINGER INGELHEIM KG (DE) | 1994-05-17 | — | — | US | disclosed |
| US-5312916-A | Process for preparing 3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine-hydrochloride | BOEHRINGER INGELHEIM KG (DE) | 1994-05-17 | — | — | US | disclosed |
| WO-1993005048-A2 | HERBICIDAL SULPHONYL UREAS, PROCESS AND INTERMEDIATES FOR PRODUCING THE SAME | BASF AKTIENGESELLSCHAFT (DE) | 1993-03-18 | — | — | WO | disclosed |
| EP-0496306-A1 | Process for the preparation of 3-amino-9,13b-dihydro-1H-dibenz-[c,f]imidazo[1,5-a]azepine hydrochloride | BOEHRINGER INGELHEIM KG (DE) | 1992-07-29 | — | — | EP | disclosed |
| EP-0469460-A1 | Herbicidal sulphonylureas, method for their preparation and intermediates | BASF Aktiengesellschaft (DE) | 1992-02-05 | — | — | EP | disclosed |
| EP-0446743-A2 | Herbicidal sulfonylureas, process for their preparation and intermediates | BASF Aktiengesellschaft (DE) | 1991-09-18 | — | — | EP | disclosed |