Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 10/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 10/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23034756 | 0.85 | OPRM1 (0.57) | OPRM1OPRD1OPRK1OPRL1HTR2A | |
| SCHEMBL3997513 | 0.82 | CCR3 (0.50) | SLC6A2SLC6A4SLC6A3CCR3 | |
| SCHEMBL23034710 | 0.79 | OPRM1 (0.64) | OPRM1OPRD1OPRK1OPRL1SLC6A2 | |
| SCHEMBL7535641 | 0.79 | OPRM1 (0.40) | OPRM1OPRD1OPRK1OPRL1HTR2A | |
| SCHEMBL23034747 | 0.78 | OPRM1 (0.67) | OPRM1OPRD1OPRK1OPRL1HTR4 | |
| SCHEMBL23034745 | 0.77 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1HTR4 | |
| SCHEMBL7536800 | 0.77 | TRPV4 (0.41) | OPRM1OPRD1OPRK1OPRL1HTR2A | |
| SCHEMBL16136133 | 0.75 | KMT2A (0.46) | HTR2AHTR2CSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28623424 | 0.75 | OPRM1 (0.53) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL23034935 | 0.74 | OPRM1 (0.48) | OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007137590-A1 | SERTINDOLE FOR THE PREVENTIVE TREATMENT OF SUICIDAL BEHAVIOUR | H. LUNDBECK A/S (DK) | 2007-12-06 | — | — | WO | disclosed |