Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL10693194 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL29000918 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL8814162 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL8814160 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL15453340 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL28811950 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL10693196 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL967740 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL27802309 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB | |
| Glycerin SCHEMBL28286835 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220851-B2 | Nucleic acid encoding calcyon, a D-1 like dopamine receptor activity modifying protein | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC. (US) | 2007-05-22 | — | — | US | disclosed |
| EP-1117688-B1 | D-1 LIKE DOPAMINE RECEPTOR ACTIVITY MODIFYING PROTEIN | MED COLLEGE GEORGIA RES INST (US) | 2005-04-27 | — | — | EP | disclosed |
| US-20030073818-A1 | D-1 like dopamine receptor activity modifying protein | BERGSON CLARE (US) | 2003-04-17 | — | — | US | disclosed |
| US-6469141-B1 | (RAMP) WHICH IS A SINGLE TRANSMEMBRANE PROTEIN, DESIGNATED P24, OR CALCYON, THAT INTERACTS WITH A C-TERMINAL INTRACELLULAR SEGMENT OF THE HD1 DOPAMINE (DA) RECEPTOR, USE IN DRUG SCREENING AND DIAGNOSTICS | MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE INC. | 2002-10-22 | — | — | US | disclosed |
| EP-1117688-A1 | D-1 LIKE DOPAMINE RECEPTOR ACTIVITY MODIFYING PROTEIN | Medical College Of Georgia Research Institute, Inc. (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000021997-A1 | D-1 LIKE DOPAMINE RECEPTOR ACTIVITY MODIFYING PROTEIN | MEDICAL COLLEGE GEORGIA RESEARCH INSTITUTE, INC. (US) | 2000-04-20 | — | — | WO | disclosed |