Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL10693194 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL29000918 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL8814160 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL15453340 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL27802309 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL10693196 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL5364722 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL28811950 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL8814162 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 | |
| Glycerin SCHEMBL28286835 | 0.94 | LMNA (0.53) | LMNAALDH1A1CA1SLC22A16CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185467-A | PROCESS FOR THE PREPARATION OF 2,2-BIS-(AMINOPHENYL)-PROPANE | BAYER AKTIENGESELLSCHAFT (DE) | 1993-02-09 | — | — | US | claimed |
| EP-2692512-B1 | Puncture sealing agent for a tire | ITW GLOBAL TIRE REPAIR INC (US) | 2017-08-16 | — | — | EP | disclosed |
| CN-105199162-A | Puncture sealing agent for a tire, and process for producing the same | ACCESSORIES MARKETING AND MFG INC | 2015-12-30 | — | — | CN | disclosed |
| US-8906251-B2 | Environmentally benign anti-icing or deicing fluids | MLI ASSOCIATES, L.L.C. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-2692512-A2 | Puncture sealing agent for a tire | Accessories Marketing, Inc. (US) | 2014-02-05 | — | — | EP | disclosed |
| EP-2001658-B1 | PUNCTURE SEALING AGENT FOR A TIRE, AND PROCESS FOR PRODUCING THE SAME | ACCESSORIES MARKETING INC (US) | 2013-12-18 | — | — | EP | disclosed |
| US-20130126779-A1 | ENVIRONMENTALLY BENIGN ANTI-ICING OR DEICING FLUIDS | MLI ASSOCIATES, LLC (US) | 2013-05-23 | — | — | US | disclosed |
| US-8377328-B2 | Environmentally benign anti-icing or deicing fluids | MLI ASSOCIATES, L.L.C. (US) | 2013-02-19 | — | — | US | disclosed |
| US-8313667-B2 | Environmentally benign anti-icing or deicing fluids employing triglyceride processing by-products | MLI ASSOCIATES, L.L.C. (US) | 2012-11-20 | — | — | US | disclosed |
| US-20120104305-A1 | ENVIRONMENTALLY BENIGN ANTI-ICING OR DEICING FLUIDS | MLI ASSOCIATES, LLC (US) | 2012-05-03 | — | — | US | disclosed |
| EP-1879977-A1 | ENVIRONMENTALLY BENING ANTI-ICING OR DEICING FLUIDS EMPLOYING TRIGLYCERIDE PROCESSING BY-PRODUCTS | MLI Associates, LLC (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20080006794-A1 | Environmentally benign anti-icing or deicing fluids employing triglyceride processing by-products | MLI ASSOCIATES, L.L.C. | 2008-01-10 | — | — | US | disclosed |
| WO-2007112010-A2 | PUNCTURE SEALING AGENT FOR A TIRE, AND PROCESS FOR PRODUCING THE SAME | ACCESSORIES MARKETING AND MANUFACTURING, INC. (US) | 2007-10-04 | — | — | WO | disclosed |
| US-20070225405-A1 | Puncture sealing agent for a tire, and process for producing the same | ITW GLOBAL TIRE REPAIR INC. | 2007-09-27 | — | — | US | disclosed |
| US-7270768-B2 | Environmentally benign anti-icing or deicing fluids employing triglyceride processing by-products | MLI ASSOCIATES, LLC (US) | 2007-09-18 | — | — | US | disclosed |
| WO-2006116254-A1 | ENVIRONMENTALLY BENING ANTI-ICING OR DEICING FLUIDS EMPLOYING TRIGLYCERIDE PROCESSING BY-PRODUCTS | MLI ASSOCIATES, LLC (US) | 2006-11-02 | — | — | WO | disclosed |
| US-20050247907-A1 | Environmentally benign anti-icing or deicing fluids employing triglyceride processing by-products | SAPIENZA RICHARD | 2005-11-10 | — | — | US | disclosed |
| EP-0941323-A1 | BONE MORPHOGENETIC PROTEIN-16 (BMP-16) COMPOSITIONS | GENETICS INSTITUTE, INC. (US) | 1999-09-15 | — | — | EP | disclosed |
| WO-1998012322-A1 | BONE MORPHOGENETIC PROTEIN-16 (BMP-16) COMPOSITIONS | GENETICS INSTITUTE, INC. (US) | 1998-03-26 | — | — | WO | disclosed |
| US-5198415-A | Glycerine and water soluble potassium or ammonium salt | EXXON PRODUCTION RESEARCH COMPANY (US) | 1993-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080006794-A1 | Environmentally benign anti-icing or deicing fluids employing triglyceride processing by-products | LIPA, DGAT2, DAGLA | LMNA 1195/4885ALDH1A1 1985/4885CA1 3168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.