Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5361934 | 0.80 | HTT (0.35) | HTTTP53ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6598839 | 0.79 | HTT (0.35) | HTTTP53ALDH1A1LMNASMN1; SMN2 | |
| Bromide SCHEMBL5359685 | 0.70 | SMYD3 (0.35) | ALDH1A1LMNASMN1; SMN2KMT2ARXFP1 | |
| Hydrochloric Acid SCHEMBL1195003 | 0.68 | CYP3A4 (0.39) | HTTTP53ALDH1A1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1538308 | 0.67 | P2RX7 (0.51) | HTTALDH1A1LMNASMN1; SMN2P2RX7 | |
| SCHEMBL6599056 | 0.67 | CYP3A4 (0.39) | HTTTP53ALDH1A1LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1194126 | 0.63 | MAPK8 (0.38) | HTTALDH1A1KMT2A | |
| SCHEMBL5424234 | 0.62 | EPHX2 (0.50) | ALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL6597480 | 0.62 | MAPK8 (0.39) | HTTALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL1194003 | 0.62 | MAPK8 (0.39) | ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7223777-B2 | Compounds for the management of aging-related and diabetic vascular complications, process for their preparation, therapeutic and cosmetic uses thereof | TORRENT PHARMACEUTICALS LTD. (IN) | 2007-05-29 | — | — | US | disclosed |