Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.65 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.56 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.56 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5373264 | 0.89 | ALDH1A1 (0.67) | ALDH1A1ACHEBCHEKMT2A | |
| SCHEMBL14578048 | 0.89 | USP2 (0.60) | SIGMAR1HIF1AEPAS1ALDH1A1ACHE | |
| Hydrochloric Acid SCHEMBL5370442 | 0.88 | USP2 (0.58) | SIGMAR1HIF1AEPAS1ALDH1A1ACHE | |
| SCHEMBL4512612 | 0.86 | ALDH1A1 (0.71) | SIGMAR1ALDH1A1ACHEBCHEKMT2A | |
| Hydrochloric Acid SCHEMBL5352820 | 0.85 | ALDH1A1 (0.60) | SIGMAR1HIF1AEPAS1FAAHALDH1A1 | |
| Hydrochloric Acid SCHEMBL3844581 | 0.85 | ALDH1A1 (0.69) | SIGMAR1ALDH1A1ACHEBCHEKMT2A | |
| Hydrochloric Acid SCHEMBL7293384 | 0.84 | HTR1A (0.66) | ALDH1A1ACHEBCHEKMT2AHTT | |
| Hydrochloric Acid SCHEMBL5358851 | 0.84 | HTR1A (0.66) | ALDH1A1ACHEBCHEKMT2AHTT | |
| SCHEMBL14577876 | 0.84 | ALDH1A1 (0.60) | ALDH1A1ACHEKMT2A | |
| Hydrochloric Acid SCHEMBL5358643 | 0.83 | EGFR (0.57) | ALDH1A1ACHEBCHECHRM4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7173132-B2 | Certain substituted 1-aryl-3-piperazine-1′-yl propanones | MOLECULAR GERIATRICS CORPORATION (US) | 2007-02-06 | — | — | US | disclosed |
| US-20030236403-A1 | Certain substituted 1-aryl-3-piperazine-1'-yl propanones | MOLECULAR GERIATRICS CORPORATION (US) | 2003-12-25 | — | — | US | disclosed |
| US-6306857-B1 | INHIBITION OF ABNORMALLY PHOSPHORYLATED | MOLECULAR GERIATRICS CORPORATION | 2001-10-23 | — | — | US | disclosed |
| US-20010025105-A1 | Certain substituted 1-aryl-3-piperazine-1'-yl propanones | MOLECULAR GERIATARICS CORPORATION | 2001-09-27 | — | — | US | disclosed |
| US-6214994-B1 | TREATMENT OF NEOPLASTIC DISEASES, BACTERIAL OR FUNGAL INFECTIONS, AND PREVENTING OR DECREASING PRODUCTION OF PHOSPHORYLATED PAIRED HELICAL FILAMENT (PHF) EPITOPES ASSOCIATED WITH ALZHEIMER'S DISEASE | MOLECULAR GERIATRICS CORPORATION | 2001-04-10 | — | — | US | disclosed |
| US-5693804-A | USEFUL IN TREATING NEOPLASTIC DISEASES, BACTERIAL OR FUNGAL INFECTIONS AND ALZHEIMER'S DISEASE | MOLECULAR GERIATRICS CORPORATION (US) | 1997-12-02 | — | — | US | disclosed |
| US-5658909-A | INHIBITION OF ABNORMALLY PHOSPHORYLATED PAIRED HELICAL FILAMENT EPITOPE FORMATION | MOLECULAR GERIATRICS CORPORATION (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1996015792-A1 | METHODS FOR TREATING OR PREVENTING ALZHEIMER'S DISEASE USING SUBSTITUTED 1-ARYL-3-PIPERAZIN-1'-YL PROPANONES | MOLECULAR GERIATRICS CORPORATION (US) | 1996-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236403-A1 | Certain substituted 1-aryl-3-piperazine-1'-yl propanones | PSEN1, PSEN2, PRNP | SIGMAR1 3020/4885HIF1A 1448/4885EPAS1 627/4885 |
| US-20010025105-A1 | Certain substituted 1-aryl-3-piperazine-1'-yl propanones | PSEN1, PSEN2, PRNP | SIGMAR1 3020/4885HIF1A 1448/4885EPAS1 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.