Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951648 | 0.95 | KMO (0.61) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL31429458 | 0.87 | KMO (0.65) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL14578726 | 0.87 | KMO (0.65) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL861732 | 0.83 | CYP1A2 (0.57) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL31301070 | 0.83 | CYP1A2 (0.57) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL319515 | 0.82 | RECQL (0.61) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL20083775 | 0.81 | CYP1A2 (0.55) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL31429798 | 0.81 | CYP1A2 (0.55) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL29117331 | 0.81 | CYP1A2 (0.55) | KMOCYP1A2P2RX7RECQLDAO | |
| SCHEMBL1326630 | 0.81 | CYP1A2 (0.58) | KMOCYP1A2P2RX7RECQLDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007028445-A1 | 6-INDOLYL-4-YL-AMINO-5-HALOGENO-2-PYRIMIDINYL-AMINO DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | WO | disclosed |