Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 3/20 | 0.49 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361431 | 0.91 | METAP1 (0.54) | KMT2AMEN1PLK4MAP1LC3BPDGFRB | |
| SCHEMBL7136821 | 0.90 | LRRK2 (0.51) | KMT2AMEN1PLK4SIRT1SIRT2 | |
| SCHEMBL7137520 | 0.90 | ALDH1A1 (0.48) | KMT2AMEN1PLK4MAP1LC3BPDGFRB | |
| SCHEMBL5361680 | 0.90 | SIRT2 (0.54) | KMT2AMEN1PLK4MAP1LC3BPDGFRB | |
| SCHEMBL5358437 | 0.90 | LRRK2 (0.49) | KMT2AMEN1PLK4MAP1LC3BPDGFRB | |
| SCHEMBL7136615 | 0.88 | SIRT2 (0.52) | KMT2AMEN1PLK4PDGFRBSIRT1 | |
| SCHEMBL5361621 | 0.86 | MEN1 (0.43) | KMT2AMEN1PLK4MAP1LC3BPDGFRB | |
| SCHEMBL7132019 | 0.86 | EGFR (0.55) | KMT2AMEN1PLK4MAP1LC3BPDGFRB | |
| SCHEMBL5366200 | 0.86 | MEN1 (0.67) | KMT2AMEN1PLK4MAP1LC3BPDGFRB | |
| SCHEMBL5363818 | 0.86 | PSEN1 (0.45) | KMT2AMEN1PLK4MAP1LC3BPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | KMT2A 4060/4885MEN1 3855/4885PLK4 42/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.