Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365589 | 0.90 | KMT2A (0.51) | SIRT2MEN1KMT2APDGFRBPLK4 | |
| SCHEMBL5361431 | 0.87 | METAP1 (0.54) | SIRT2METAP1MEN1KMT2APDGFRB | |
| SCHEMBL7131906 | 0.87 | SIRT1 (0.42) | SIRT2PARP1METAP1KDRMEN1 | |
| SCHEMBL7137977 | 0.86 | PLK4 (0.44) | SIRT2PARP1KDRMEN1KMT2A | |
| SCHEMBL7136821 | 0.86 | LRRK2 (0.51) | SIRT2MEN1KMT2APLK4SIRT1 | |
| SCHEMBL7137520 | 0.86 | ALDH1A1 (0.48) | SIRT2MEN1KMT2APDGFRBPLK4 | |
| SCHEMBL5358437 | 0.86 | LRRK2 (0.49) | SIRT2PARP1MEN1KMT2APDGFRB | |
| SCHEMBL7134789 | 0.85 | PIM1 (0.45) | SIRT2PARP1KDRPLK4SIRT1 | |
| SCHEMBL7136615 | 0.84 | SIRT2 (0.52) | SIRT2PARP1KDRMEN1KMT2A | |
| SCHEMBL7132019 | 0.83 | EGFR (0.55) | SIRT2MEN1KMT2APDGFRBPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | SIRT2 4180/4885PARP1 1584/4885METAP1 3119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.