Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378747 | 0.93 | SLC6A2 (0.51) | SLC6A2SLC6A4MEN1KMT2AMCHR1 | |
| SCHEMBL5378543 | 0.91 | BCHE (0.48) | SLC6A2SLC6A4F2HDAC6ACHE | |
| SCHEMBL5378029 | 0.91 | SLC6A2 (0.47) | SLC6A2SLC6A4MEN1KMT2AF2 | |
| SCHEMBL5367994 | 0.84 | MEN1 (0.52) | SLC6A2SLC6A4MEN1KMT2AF2 | |
| SCHEMBL5365749 | 0.79 | SLC6A2 (0.45) | SLC6A2SLC6A4MEN1KMT2AHDAC6 | |
| SCHEMBL5369707 | 0.79 | HDAC6 (0.48) | SLC6A2SLC6A4MEN1KMT2AF2 | |
| SCHEMBL5203573 | 0.79 | F2 (0.57) | SLC6A2SLC6A4MEN1KMT2AF2 | |
| SCHEMBL1063477 | 0.77 | ALDH1A1 (0.56) | MEN1KMT2AF2MCHR1KDM4E | |
| SCHEMBL5378753 | 0.74 | SLC6A2 (0.49) | SLC6A2SLC6A4MEN1KMT2AMCHR1 | |
| SCHEMBL1062782 | 0.72 | ALDH1A1 (0.50) | SLC6A2SLC6A4MEN1KMT2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | claimed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | claimed |
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | claimed |