Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365744 | 0.84 | SLC6A2 (0.47) | MEN1KMT2ASLC6A2SLC6A4MCHR1 | |
| SCHEMBL5369707 | 0.80 | HDAC6 (0.48) | MEN1KMT2ASLC6A2SLC6A4LMNA | |
| SCHEMBL5203573 | 0.80 | F2 (0.57) | MEN1KMT2ASLC6A2SLC6A4HDAC6 | |
| SCHEMBL5378543 | 0.78 | BCHE (0.48) | SLC6A2SLC6A4HDAC6F2 | |
| SCHEMBL5378029 | 0.78 | SLC6A2 (0.47) | MEN1KMT2ASLC6A2SLC6A4HDAC6 | |
| SCHEMBL5378747 | 0.78 | SLC6A2 (0.51) | MEN1KMT2ASLC6A2SLC6A4MCHR1 | |
| SCHEMBL5367998 | 0.78 | MEN1 (0.52) | MEN1KMT2AROCK1SLC6A2SLC6A4 | |
| SCHEMBL1061695 | 0.74 | MGLL (0.59) | MEN1KMT2AMCHR1ALDH1A1F2 | |
| SCHEMBL1056538 | 0.73 | F2 (0.58) | MEN1KMT2AMCHR1ALDH1A1F2 | |
| SCHEMBL5733657 | 0.72 | GAA (0.55) | MEN1KMT2ASLC6A2SLC6A4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189739-B2 | Compounds and methods to treat cardiac failure and other disorders | SCIOS, INC. (US) | 2007-03-13 | — | — | US | claimed |
| EP-1080078-B1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC (US) | 2006-02-01 | — | — | EP | claimed |
| EP-1080078-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 2001-03-07 | — | — | EP | claimed |
| WO-1999061426-A1 | HETEROCYCLIC COMPOUNDS AND METHODS TO TREAT CARDIAC FAILURE AND OTHER DISORDERS | SCIOS INC. (US) | 1999-12-02 | — | — | WO | claimed |