Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.58 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.46 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358943 | 0.86 | PLK4 (0.48) | EGFRERBB2PDGFRBIGF1RNOX4 | |
| SCHEMBL5362076 | 0.84 | LRRK2 (0.52) | EGFRSIRT1MAP1LC3BSIRT2SIRT3 | |
| SCHEMBL7134818 | 0.83 | MAP1LC3B (0.60) | EGFRSIRT1MAP1LC3BSIRT2SIRT3 | |
| SCHEMBL7131372 | 0.82 | SIRT1 (0.48) | EGFRPDGFRBSIRT1MAP1LC3BSIRT2 | |
| SCHEMBL5362718 | 0.81 | MAP1LC3B (0.67) | EGFRSIRT1MAP1LC3BSIRT2SIRT3 | |
| SCHEMBL5363945 | 0.81 | ERBB2 (0.58) | EGFRERBB2IGF1RSIRT1MAP1LC3B | |
| SCHEMBL5364415 | 0.80 | EGFR (0.45) | EGFRERBB2PDGFRBIGF1RNOX4 | |
| SCHEMBL7132019 | 0.80 | EGFR (0.55) | EGFRERBB2PDGFRBIGF1RSIRT1 | |
| SCHEMBL7132917 | 0.80 | EGFR (0.51) | EGFRERBB2PDGFRBIGF1RNOX4 | |
| SCHEMBL5361431 | 0.79 | METAP1 (0.54) | PDGFRBSIRT1MAP1LC3BSIRT2SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | EGFR 286/4885ERBB2 19/4885PDGFRB 52/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.