Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL341644 | 1.00 | HCRTR1 (0.41) | HCRTR1HCRTR2MEN1KMT2APOLB | |
| SCHEMBL5379739 | 1.00 | HCRTR1 (0.41) | HCRTR1HCRTR2MEN1KMT2APOLB | |
| SCHEMBL5369190 | 0.87 | HTR2A (0.46) | CYP2C19HTR2AKCNH2 | |
| SCHEMBL342217 | 0.87 | HTR2A (0.46) | CYP2C19HTR2AKCNH2 | |
| SCHEMBL5364125 | 0.85 | SIGMAR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL339247 | 0.85 | SIGMAR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL5370078 | 0.85 | SIGMAR1 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL341553 | 0.82 | HCRTR2 (0.43) | HCRTR1HCRTR2MEN1KMT2APOLB | |
| SCHEMBL342349 | 0.81 | HCRTR2 (0.43) | HCRTR1HCRTR2MEN1KMT2AALDH1A1 | |
| SCHEMBL5361616 | 0.79 | HTR2A (0.40) | CYP2C19HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217719-B2 | Spiroazacyclic compounds as monoamine receptor modulators | ACADIA PHARMACEUTICALS INC. (US) | 2007-05-15 | — | — | US | claimed |