Sugi Predict

Sugi Predict / Compounds / SCHEMBL5366229

SCHEMBL5366229

SCHEMBL5366229

CCN1CCN(c2cn(S(=O)(=O)c3cc(OC)ccc3OC)c3cc(Cl)ccc23)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 17/20 1.00
▸ L3MBTL1 Q9Y468 2/20 0.49
▸ USP2 O75604 1/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ LMNA P02545 1/20 0.49
▸ HTT P42858 1/20 0.49
▸ KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5356119 0.88 HTR6 (0.78) HTR6L3MBTL1USP2ALDH1A1LMNA
SCHEMBL5367378 0.83 HTR6 (0.71) HTR6L3MBTL1USP2ALDH1A1LMNA
SCHEMBL5412647 0.80 HTR6 (0.84) HTR6
SCHEMBL5356699 0.79 HTR6 (0.85) HTR6
SCHEMBL5352976 0.78 HTR6 (0.80) HTR6
SCHEMBL5356044 0.78 HTR6 (0.73) HTR6
SCHEMBL5372081 0.77 HTR6 (0.80) HTR6ALDH1A1HTT
SCHEMBL16835423 0.77 HTR6 (1.00) HTR6
SCHEMBL5375838 0.77 HTR6 (0.78) HTR6
SCHEMBL5443199 0.77 HTR6 (0.85) HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007138611-A1 3-(HETEROCYCLYL)-N-(ARYLSULFONYL)INDOLE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS SUVEN LIFE SCIENCES LIMITED (IN) 2007-12-06 — — WO claimed
WO-2007138611-A1 3-(HETEROCYCLYL)-N-(ARYLSULFONYL)INDOLE DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS SUVEN LIFE SCIENCES LIMITED (IN) 2007-12-06 — — WO disclosed