Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | RAF1 | P04049 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 2/20 | 0.54 |
| ▸ | PLK1 | P53350 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | ARAF | P10398 | 1/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | MYOC | Q99972 | 1/20 | 0.54 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7131079 | 0.91 | MAPT (0.53) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7131050 | 0.91 | RET (0.56) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7133810 | 0.90 | MAPT (0.62) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7138552 | 0.88 | ADAMTS5 (0.56) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7137030 | 0.88 | ADAMTS5 (0.54) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7139901 | 0.87 | MAPT (0.48) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7131328 | 0.87 | MAPT (0.58) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7135549 | 0.86 | MAOA (0.54) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL5358659 | 0.86 | LRRK2 (0.69) | NTRK1MAPTRAF1APPMAP1LC3B | |
| SCHEMBL7138859 | 0.81 | LRRK2 (0.67) | NTRK1MAPTRAF1APPMAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | NTRK1 223/4885MAPT 3048/4885RAF1 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.