Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 3/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.58 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368841 | 0.84 | CSNK1D (0.43) | CSNK1DCSNK1A1CSNK1EL3MBTL1GMNN | |
| SCHEMBL5376968 | 0.82 | ERN1 (0.49) | CSNK1DCSNK1A1CSNK1EL3MBTL1GMNN | |
| SCHEMBL7138320 | 0.82 | CSNK1D (0.50) | CSNK1DCSNK1A1CSNK1EL3MBTL1GMNN | |
| SCHEMBL5368885 | 0.82 | KDM4E (0.47) | ALDH1A1LMNAMAPTLRRK2MDM2 | |
| SCHEMBL5373328 | 0.81 | LRRK2 (0.52) | CSNK1DCSNK1A1GMNNLMNATP53 | |
| SCHEMBL5358747 | 0.81 | PLK4 (0.60) | ALDH1A1MAPTHPGDSMN1; SMN2TDP1 | |
| SCHEMBL5358789 | 0.81 | PDPK1 (0.40) | CSNK1DCSNK1A1CSNK1EL3MBTL1GMNN | |
| SCHEMBL7138342 | 0.80 | ALDH1A1 (0.53) | ALDH1A1MAPTTDP1LRRK2PLK4 | |
| SCHEMBL7134866 | 0.80 | LRRK2 (0.50) | L3MBTL1ALDH1A1MAPTHPGDRAB9A | |
| SCHEMBL7139982 | 0.80 | NPC1 (0.60) | MDM2PLK4CCNE1CDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | CSNK1D 674/4885CSNK1A1 429/4885CSNK1E 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.