Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138252 | 0.89 | ERBB2 (0.45) | ALDH1A1MAPTKMT2AKDM4ECTDSP1 | |
| SCHEMBL7138253 | 0.89 | KDM1A (0.54) | ALDH1A1MAPTKMT2ATDP1PLK4 | |
| SCHEMBL5366009 | 0.87 | ERBB2 (0.62) | ALDH1A1MAPTKMT2AKDM4ECTDSP1 | |
| SCHEMBL5357895 | 0.86 | IGF1R (0.53) | ALDH1A1MAPTKMT2AKDM4EPLK4 | |
| SCHEMBL5358747 | 0.85 | PLK4 (0.60) | ALDH1A1MAPTKMT2AKDM4ETDP1 | |
| SCHEMBL7132141 | 0.84 | KMT2A (0.53) | ALDH1A1MAPTKMT2AKDM4ECTDSP1 | |
| SCHEMBL5366852 | 0.83 | LRRK2 (0.50) | ALDH1A1MAPTKMT2ATDP1PLK4 | |
| SCHEMBL7134866 | 0.81 | LRRK2 (0.50) | ALDH1A1MAPTKMT2ATDP1LRRK2 | |
| SCHEMBL5368885 | 0.81 | KDM4E (0.47) | ALDH1A1MAPTKMT2AKDM4EPLK4 | |
| SCHEMBL5367223 | 0.80 | CSNK1D (0.58) | ALDH1A1MAPTTDP1PLK4LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |