Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | LCK | P06239 | 3/20 | 0.52 |
| ▸ | FYN | P06241 | 3/20 | 0.52 |
| ▸ | YES1 | P07947 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | FCER2 | P06734 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362182 | 0.91 | RET (0.66) | SRCRETKDRLCKFYN | |
| SCHEMBL5368963 | 0.85 | APP (0.64) | SRCKDRLCKFYNYES1 | |
| SCHEMBL5369336 | 0.85 | MGAT2 (0.52) | SRCRETKDRLCKFYN | |
| SCHEMBL7132943 | 0.85 | PSEN1 (0.57) | SRCRETKDRLCKFYN | |
| SCHEMBL7138289 | 0.83 | SRC (0.58) | SRCKDRLCKFYNYES1 | |
| SCHEMBL7136883 | 0.82 | SRC (0.58) | SRCKDRLCKFYNYES1 | |
| SCHEMBL7132251 | 0.81 | PSEN1 (0.54) | SRCRETKDRCDK2NTRK1 | |
| SCHEMBL5365190 | 0.81 | PSEN1 (0.60) | SRCRETKDRPDGFRBCDK2 | |
| SCHEMBL7136913 | 0.81 | LRRK2 (0.57) | SRCKDRCDK2NTRK1FCER2 | |
| SCHEMBL5369843 | 0.81 | SRC (0.59) | SRCKDRLCKFYNYES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | SRC 189/4885RET 283/4885KDR 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.