Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAT2 | Q10469 | 2/20 | 0.52 |
| ▸ | MOGAT2 | Q3SYC2 | 4/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5365870 | 0.92 | RET (0.56) | MGAT2MOGAT2RETPRKDCLRRK2 | |
| SCHEMBL5367769 | 0.87 | MOGAT2 (0.56) | MGAT2MOGAT2PDGFRBAPPMAPT | |
| SCHEMBL5358368 | 0.87 | MOGAT2 (0.61) | MGAT2MOGAT2LRRK2APPMAPT | |
| SCHEMBL7136258 | 0.87 | MGAT2 (0.54) | MGAT2MOGAT2PRKDCLRRK2 | |
| SCHEMBL5367635 | 0.85 | SRC (0.57) | RETSRCLCKFYNYES1 | |
| SCHEMBL5361465 | 0.84 | MOGAT2 (0.59) | MGAT2MOGAT2PRKDCLRRK2APP | |
| SCHEMBL7136121 | 0.83 | MGAT2 (0.54) | MGAT2MOGAT2PRKDCLRRK2 | |
| SCHEMBL5370221 | 0.83 | MOGAT2 (0.57) | MGAT2MOGAT2KDRAPPMAPT | |
| SCHEMBL7136606 | 0.83 | MGAT2 (0.55) | MGAT2MOGAT2PRKDCLRRK2MAPT | |
| SCHEMBL5361301 | 0.82 | MOGAT2 (0.56) | MGAT2MOGAT2RETPDGFRBLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197382-A1 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | FRK, PTK2, DSTYK | MGAT2 4714/4885MOGAT2 1159/4885RET 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.